| Gene Information | |
|---|---|
| Gene Name | HADHB |
| Organism | Homo sapiens (Human) |
| Gene Length | 474 |
| Protein Names | Trifunctional enzyme subunit beta, mitochondrial (TP-beta) [Includes: 3-ketoacyl-CoA thiolase (EC 2.3.1.155) (EC 2.3.1.16) (Acetyl-CoA acyltransferase) (Beta-ketothiolase)] |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 950 ( ENSG00000138029 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | P55084 |
| Gene Card | HADHB |
| Uniprot ID | P55084 |
| Pfam | PF02803; PF00108 |
| In ASD | no |
| Allosteric Prediction | yes (0.082840255) |
| Ortholog in Animals | Alpaca_ HADHB ( ortholog_one2one ) GuineaPig_ HADHB ( ortholog_one2one ) Macaque_ HADHB ( ortholog_one2one ) Mouse_ Hadhb ( ortholog_one2one ) Pig_ HADHB ( ortholog_one2one ) Rat_ Hadhb ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | ACAA1, ACAA2, ACAT2, ACAT1 |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.066667(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 5ZQZ (EM 4.20A ) 5ZRV (EM 7.70A ) 6DV2 (X-ray 3.60A ) |
| DBSNP | rs780351691 rs121913132 rs773127211 rs371159065 rs17851200 rs1166120479 rs121913133 rs121913131 rs57969630 rs751772298 rs1558357879 rs891954464 rs121913134 |
| Subcellular location [CC] | Mitochondrion {ECO:0000269|PubMed:21527675}. Mitochondrion inner membrane {ECO:0000269|PubMed:21527675}. Mitochondrion outer membrane {ECO:0000269|PubMed:21527675}. Endoplasmic reticulum {ECO:0000269|PubMed:21527675}. Note=Protein stability and association with membranes require HADHA. {ECO:0000269|PubMed:29915090}. |
| Mouse PG classification | NA |
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