| Gene Information | |
|---|---|
| Gene Name | HADH |
| Organism | Homo sapiens (Human) |
| Gene Length | 314 |
| Protein Names | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial (HCDH) (EC 1.1.1.35) (Medium and short-chain L-3-hydroxyacyl-coenzyme A dehydrogenase) (Short-chain 3-hydroxyacyl-CoA dehydrogenase) |
| Target Name | hydroxyacyl-coenzyme a dehydrogenase, mitochondrial |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000138796 ) |
| Evolutionary Stage | Cellular_organisms |
| AlphaFoldDB | Q16836 |
| Gene Card | HADH |
| Uniprot ID | Q16836 |
| Pfam | PF00725; PF02737 |
| In ASD | no |
| Allosteric Prediction | yes (0.685382634) |
| Ortholog in Animals | Alpaca_ HADH ( ortholog_one2one ) Dog_ HADH ( ortholog_one2one ) GuineaPig_ HADH ( ortholog_one2one ) Macaque_ HADH ( ortholog_one2one ) Mouse_ Hadh ( ortholog_one2one ) Pig_ HADH ( ortholog_one2one ) Rat_ Hadh ( ortholog_one2one ) Rabbit_ HADH ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | EHHADH, CRYL1, HADHA |
| Tissue | NA |
| Tissue Specificity | Expressed in liver, kidney, pancreas, heart and skeletal muscle. {ECO:0000269|PubMed:8687463}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1F0Y (X-ray 1.80A ) 1F12 (X-ray 2.40A ) 1F14 (X-ray 2.30A ) 1F17 (X-ray 2.30A ) 1IL0 (X-ray 2.20A ) 1LSJ (X-ray 2.50A ) 1LSO (X-ray 2.60A ) 1M75 (X-ray 2.30A ) 1M76 (X-ray 2.15A ) 2HDH (X-ray 2.20A ) 3HAD (X-ray 2.00A ) 3RQS (X-ray 2.00A ) |
| DBSNP | rs137853101 rs137853102 rs4956145 rs1051519 rs146036912 rs137853103 |
| Subcellular location [CC] | Mitochondrion matrix {ECO:0000305|PubMed:8687463}. |
| Mouse PG classification | NA |
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