| Gene Information | |
|---|---|
| Gene Name | HADH |
| Organism | Homo sapiens (Human) |
| Gene Length | 763 |
| Protein Names | Trifunctional enzyme subunit alpha, mitochondrial (78 kDa gastrin-binding protein) (Monolysocardiolipin acyltransferase) (EC 2.3.1.-) (TP-alpha) [Includes: Long-chain enoyl-CoA hydratase (EC 4.2.1.17); Long chain 3-hydroxyacyl-CoA dehydrogenase (EC 1.1.1.211)] |
| Target Name | hydroxyacyl-coenzyme a dehydrogenase, mitochondrial |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000138796 ) |
| Evolutionary Stage | Cellular_organisms |
| AlphaFoldDB | P40939 |
| Gene Card | HADHA |
| Uniprot ID | P40939 |
| Pfam | PF00725; PF02737; PF00378 |
| In ASD | no |
| Allosteric Prediction | yes (0.685382634) |
| Ortholog in Animals | Alpaca_ HADH ( ortholog_one2one ) Dog_ HADH ( ortholog_one2one ) GuineaPig_ HADH ( ortholog_one2one ) Macaque_ HADH ( ortholog_one2one ) Mouse_ Hadh ( ortholog_one2one ) Pig_ HADH ( ortholog_one2one ) Rat_ Hadh ( ortholog_one2one ) Rabbit_ HADH ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | EHHADH, CRYL1, HADHA |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001516(Rat);0.047059(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 5ZQZ (EM 4.20A ) 5ZRV (EM 7.70A ) 6DV2 (X-ray 3.60A ) |
| DBSNP | rs137852773 rs137852774 rs137852772 rs2229420 rs137852769 |
| Subcellular location [CC] | Mitochondrion {ECO:0000269|PubMed:29915090}. Mitochondrion inner membrane {ECO:0000269|PubMed:29915090}. Note=Protein stability and association with mitochondrion inner membrane do not require HADHB. {ECO:0000269|PubMed:29915090}. |
| Mouse PG classification | NA |
| click here to return to the previous page | |