Gene Information
Gene NameHABP4
OrganismHomo sapiens (Human)
Gene Length413
Protein NamesIntracellular hyaluronan-binding protein 4 (IHABP-4) (IHABP4) (Hyaluronan-binding protein 4) (Ki-1/57 intracellular antigen)
Target Nameintracellular hyaluronan-binding protein 4
Target TypeNA
Gene Age950 ( ENSG00000130956 )
Evolutionary StageVertebrata
AlphaFoldDBQ5JVS0
Gene CardHABP4
Uniprot IDQ5JVS0
PfamPF04774; PF16174
In ASDno
Allosteric Predictionno (-0.012381885)
Ortholog in AnimalsAlpaca_ HABP4 ( ortholog_one2one )
Dog_ HABP4 ( ortholog_one2one )
GuineaPig_ HABP4 ( ortholog_one2one )
Macaque_ HABP4 ( ortholog_one2one )
Mouse_ Habp4 ( ortholog_one2one )
Pig_ HABP4 ( ortholog_one2one )
Rat_ Habp4 ( ortholog_one2one )
OhnologsSERBP1
ParalogsSERBP1
TissueNA
Tissue SpecificityHighly expressed in brain, heart, and kidney, and moderately expressed in skeletal muscle. Also expressed in a variety of tumor cell lines and in activated but not resting leukocytes. {ECO:0000269|PubMed:12505151, ECO:0000269|PubMed:9523163}.
Pharmacological Animal ModelsNULL(Chimpanzee);NULL(Mouse);0.001225(Rat);0.029907(Rabbit)
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB NA 
DBSNP NA 
Subcellular location [CC]Nucleus {ECO:0000269|PubMed:14699138, ECO:0000269|PubMed:16455055, ECO:0000269|PubMed:16879614, ECO:0000269|PubMed:19523114, ECO:0000269|PubMed:9523163}. Cytoplasm {ECO:0000269|PubMed:14699138, ECO:0000269|PubMed:16455055, ECO:0000269|PubMed:16879614, ECO:0000269|PubMed:19523114, ECO:0000269|PubMed:9523163}. Cytoplasm, Stress granule {ECO:0000269|PubMed:21771594}. Cytoplasm, sarcoplasm {ECO:0000250|UniProtKB:A1L1K8}. Nucleus, nuclear body {ECO:0000269|PubMed:19523114}. Nucleus, nucleolus {ECO:0000269|PubMed:19523114}. Nucleus speckle {ECO:0000269|PubMed:19523114}. Nucleus, Cajal body {ECO:0000269|PubMed:19523114}. Nucleus, gem {ECO:0000269|PubMed:19523114}. Note=Transported into the nuclear compartment in activated leukocytes (PubMed:9523163). Inhibition of methylation alters its distribution between the nuclear and cytoplasmic compartments (PubMed:16879614, PubMed:19523114). Methylation may be required for its localization in subnuclear structures, such as nucleoli, nuclear speckles, Cajal bodies and Gemini of coiled bodies (gems) (PubMed:19523114). Colocalizes with FMR1, FXR1 and FXR2 in cytoplasmic stress granules (PubMed:21771594). In myocardial cells, localization at the sarcoplasm is reduced in response to mechanical stress (By similarity). {ECO:0000250|UniProtKB:A1L1K8, ECO:0000269|PubMed:16879614, ECO:0000269|PubMed:19523114, ECO:0000269|PubMed:21771594, ECO:0000269|PubMed:9523163}.
Mouse PG classificationNA
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