| Gene Information | |
|---|---|
| Gene Name | KLF1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 362 |
| Protein Names | Krueppel-like factor 1 (Erythroid krueppel-like transcription factor) (EKLF) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 1292 ( ENSG00000105610 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q13351 |
| Gene Card | KLF1 |
| Uniprot ID | Q13351 |
| Pfam | PF16832; PF16833; PF00096 |
| In ASD | no |
| Allosteric Prediction | no (-0.736050238) |
| Ortholog in Animals | Alpaca_ KLF1 ( ortholog_one2one ) Dog_ KLF1 ( ortholog_one2one ) GuineaPig_ KLF1 ( ortholog_one2one ) Macaque_ KLF1 ( ortholog_one2one ) Mouse_ Klf1 ( ortholog_one2one ) Pig_ KLF1 ( ortholog_one2one ) Rat_ Klf1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | KLF17, KLF11, KLF18, SP8, KLF15, KLF13, SP9, SP7, KLF16, KLF5, KLF12, KLF7, KLF3, KLF2, SP5, SP6, KLF8, KLF14, KLF6, KLF10, KLF4, KLF9 |
| Tissue | bone.marrow |
| Tissue Specificity | Expression restricted to adult bone marrow and fetal liver. Not expressed in myeloid nor lymphoid cell lines. {ECO:0000269|PubMed:8924208, ECO:0000269|PubMed:9119377}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
|
| PDB | 2L2I (NMR - ) 2MBH (NMR - ) 2N23 (NMR - ) |
| DBSNP | rs483352842 rs2072597 rs2072596 rs387907598 rs137852688 rs137852688 rs267607201 rs140252918 rs483352841 rs387907599 rs483352839 |
| Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:21055716, ECO:0000269|PubMed:25585695}. Note=Colocalizes with SUMO1 in nuclear speckles. {ECO:0000250}. |
| Mouse PG classification | HPG |
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