| Gene Information | |
|---|---|
| Gene Name | XPNPEP2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 674 |
| Protein Names | Xaa-Pro aminopeptidase 2 (EC 3.4.11.9) (Aminoacylproline aminopeptidase) (Membrane-bound aminopeptidase P) (Membrane-bound APP) (Membrane-bound AmP) (mAmP) (X-Pro aminopeptidase 2) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 950 ( ENSG00000122121 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | O43895 |
| Gene Card | XPNPEP2 |
| Uniprot ID | O43895 |
| Pfam | PF01321; PF00557; PF16188 |
| In ASD | no |
| Allosteric Prediction | no (-0.731228122) |
| Ortholog in Animals | Alpaca_ XPNPEP2 ( ortholog_one2one ) Dog_ XPNPEP2 ( ortholog_one2one ) GuineaPig_ XPNPEP2 ( ortholog_one2one ) Macaque_ XPNPEP2 ( ortholog_one2one ) Mouse_ Xpnpep2 ( ortholog_one2one ) Pig_ XPNPEP2 ( ortholog_one2one ) Rat_ Xpnpep2 ( ortholog_one2one ) Rabbit_ XPNPEP2 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | XPNPEP1, METAP1D, PA2G4, METAP2, METAP1, XPNPEP3, PEPD |
| Tissue | duodenum, kidney, small.intestine, small.intestine.Peyers.patch |
| Tissue Specificity | Expressed in kidney, lung, heart, placenta, liver, small intestine and colon. No expression in brain, skeletal muscle, pancreas, spleen, thymus, prostate, testis and ovary. {ECO:0000269|PubMed:9375790}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs138365897 rs61733030 rs41311662 |
| Subcellular location [CC] | Cell membrane {ECO:0000250|UniProtKB:Q95333}; Lipid-anchor, GPI-anchor {ECO:0000250|UniProtKB:Q95333}. |
| Mouse PG classification | NA |
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