| Gene Information | |
|---|---|
| Gene Name | CGNL1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1302 |
| Protein Names | Cingulin-like protein 1 (Junction-associated coiled-coil protein) (Paracingulin) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 544 ( ENSG00000128849 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | Q0VF96 |
| Gene Card | CGNL1 |
| Uniprot ID | Q0VF96 |
| Pfam | PF01576 |
| In ASD | no |
| Allosteric Prediction | no (-0.852010537) |
| Ortholog in Animals | Alpaca_ CGNL1 ( ortholog_one2one ) Dog_ CGNL1 ( ortholog_one2one ) GuineaPig_ CGNL1 ( ortholog_one2one ) Macaque_ CGNL1 ( ortholog_one2one ) Mouse_ Cgnl1 ( ortholog_one2one ) Pig_ CGNL1 ( ortholog_one2one ) Rat_ Cgnl1 ( ortholog_one2one ) Rabbit_ CGNL1 ( ortholog_one2one ) |
| Ohnologs | CGN |
| Paralogs | CGN, MYO3A, MYH10, TMF1, MYO7B, MYO1D, CCDC102B, MYH1, MYO19, MYO1C, MYH3, MYH7, MYO1A, MYO15A, MYH9, MYO18A, MYO1E, MYH14, MYH2, MYH15, MYO3B, CCDC102A, MYO5A, MYO1G, MYO1H, MYO18B, MYO5C, MYO9B, MYO7A, MYH7B, MYO5B, MYH11, MYO16, MYO10, MYH8, MYH6, MYO9A, MYO6, MYH4, CCDC158, MYO1B, MYO1F, MYH13 |
| Tissue | NA |
| Tissue Specificity | Smooth muscle, spleen, testis, fetal brain, amygdala, corpus callosum, cerebellum, thalamus and subthalamic nucleus of adult brain. {ECO:0000269|PubMed:11214970}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs1280395 rs7182648 rs1280396 rs1620402 rs16977594 |
| Subcellular location [CC] | Cell junction, tight junction {ECO:0000250|UniProtKB:Q6AW69}. Note=Localizes to the apical junction complex composed of tight and adherens junctions (PubMed:22891260). In the liver and kidney, it is also found along non-junctional actin filament bundles in addition to the apical junction (By similarity). {ECO:0000250|UniProtKB:Q6AW69, ECO:0000269|PubMed:22891260}. |
| Mouse PG classification | NA |
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