| Gene Information | |
|---|---|
| Gene Name | KIAA1338 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1649 |
| Protein Names | eIF-2-alpha kinase GCN2 (EC 2.7.11.1) (Eukaryotic translation initiation factor 2-alpha kinase 4) (GCN2-like protein) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | Q9P2K8 |
| Gene Card | EIF2AK4 |
| Uniprot ID | Q9P2K8 |
| Pfam | PF12745; PF00069; PF05773; PF13393 |
| In ASD | yes |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Widely expressed (PubMed:10504407). Expressed in lung, smooth muscle cells and macrophages (PubMed:24292273). {ECO:0000269|PubMed:10504407, ECO:0000269|PubMed:24292273}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 6N3L (X-ray 2.61A ) 6N3N (X-ray 3.01A ) 6N3O (X-ray 2.40A ) 7E2K (X-ray 2.04A ) 7E2M (X-ray 2.35A ) 7QQ6 (X-ray 2.80A ) 7QWK (X-ray 2.30A ) |
| DBSNP | rs35509999 rs34439704 rs2291627 rs587777106 rs757852728 rs34665481 rs55781333 rs35602605 rs35480871 rs55721315 |
| Subcellular location [CC] | Cytoplasm {ECO:0000250|UniProtKB:Q9QZ05}. |
| Mouse PG classification | NA |
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