| Gene Information | |
|---|---|
| Gene Name | NFAM1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 270 |
| Protein Names | NFAT activation molecule 1 (Calcineurin/NFAT-activating ITAM-containing protein) (NFAT-activating protein with ITAM motif 1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 132 ( ENSG00000235568 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | Q8NET5 |
| Gene Card | NFAM1 |
| Uniprot ID | Q8NET5 |
| Pfam | NA |
| In ASD | no |
| Allosteric Prediction | no (-0.814805436) |
| Ortholog in Animals | Alpaca_ NFAM1 ( ortholog_one2one ) Dog_ NFAM1 ( ortholog_one2one ) GuineaPig_ NFAM1 ( ortholog_one2one ) Macaque_ NFAM1 ( ortholog_one2one ) Mouse_ Nfam1 ( ortholog_one2one ) Pig_ NFAM1 ( ortholog_one2one ) Rat_ Nfam1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | appendix, bone.marrow, spleen, whole.blood |
| Tissue Specificity | Highly expressed in neutrophils, primary monocytes, mast cells, monocytic cell lines and lymphocytes. Also expressed in spleen B and T-cells, and lung. Expressed at low level in non-immune tissue. {ECO:0000269|PubMed:12615919, ECO:0000269|PubMed:15143214}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs34296033 rs17003048 |
| Subcellular location [CC] | Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Note=Partially recruited to lipid rafts upon BCR stimulation. {ECO:0000250}. |
| Mouse PG classification | NA |
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