| Gene Information | |
|---|---|
| Gene Name | IL6ST |
| Organism | Homo sapiens (Human) |
| Gene Length | 918 |
| Protein Names | Interleukin-6 receptor subunit beta (IL-6 receptor subunit beta) (IL-6R subunit beta) (IL-6R-beta) (IL-6RB) (CDw130) (Interleukin-6 signal transducer) (Membrane glycoprotein 130) (gp130) (Oncostatin-M receptor subunit alpha) (CD antigen CD130) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 544 ( ENSG00000134352 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | P40189 |
| Gene Card | IL6ST |
| Uniprot ID | P40189 |
| Pfam | PF00041; PF09240; PF06328 |
| In ASD | no |
| Allosteric Prediction | yes (0.63251058) |
| Ortholog in Animals | Alpaca_ IL6ST ( ortholog_one2one ) Dog_ IL6ST ( ortholog_one2one ) GuineaPig_ IL6ST ( ortholog_one2one ) Macaque_ IL6ST ( ortholog_one2one ) Mouse_ Il6st ( ortholog_one2one ) Pig_ IL6ST ( ortholog_one2one ) Rat_ Il6st ( ortholog_one2one ) Rabbit_ IL6ST ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | CRLF1, IL13RA2, IL11RA, IL13RA1, CNTFR, IL2RG, CRLF2, IL31RA, IL3RA, IL12RB1, CSF3R, IL12RB2, GHR, CSF2RA, IL6R, IL27RA, IL23R, LIFR, OSMR, IL5RA, EBI3, PRLR, LEPR |
| Tissue | NA |
| Tissue Specificity | Found in all the tissues and cell lines examined (PubMed:2261637). Expression not restricted to IL6 responsive cells (PubMed:2261637). {ECO:0000269|PubMed:2261637}.; [Isoform 2]: Expressed in blood serum (at protein level) (PubMed:24629561). {ECO:0000269|PubMed:24629561}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.084211(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1BJ8 (NMR - ) 1BQU (X-ray 2.00A ) 1I1R (X-ray 2.40A ) 1P9M (X-ray 3.65A ) 1PVH (X-ray 2.50A ) 3L5H (X-ray 3.60A ) 3L5I (X-ray 1.90A ) 3L5J (X-ray 3.04A ) 7U7N (EM 3.47A ) |
| DBSNP | rs1063560 rs2228044 rs199905033 rs2228043 rs2228046 rs34417936 |
| Subcellular location [CC] | [Isoform 1]: Cell membrane {ECO:0000269|PubMed:19915009}; Single-pass type I membrane protein {ECO:0000255}.; [Isoform 2]: Secreted {ECO:0000269|PubMed:24629561}. |
| Mouse PG classification | NA |
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