| Gene Information | |
|---|---|
| Gene Name | ADAR |
| Organism | Homo sapiens (Human) |
| Gene Length | 1226 |
| Protein Names | Double-stranded RNA-specific adenosine deaminase (DRADA) (EC 3.5.4.37) (136 kDa double-stranded RNA-binding protein) (p136) (Interferon-inducible protein 4) (IFI-4) (K88DSRBP) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 987 ( ENSG00000160710 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | P55265 |
| Gene Card | ADAR |
| Uniprot ID | P55265 |
| Pfam | PF02137; PF00035; PF02295 |
| In ASD | no |
| Allosteric Prediction | no (-0.522754936) |
| Ortholog in Animals | Alpaca_ ADAR ( ortholog_one2one ) Dog_ ADAR ( ortholog_one2one ) GuineaPig_ ADAR ( ortholog_one2one ) Macaque_ ADAR ( ortholog_one2one ) Mouse_ Adar ( ortholog_one2one ) Pig_ ADAR ( ortholog_one2one ) Rat_ Adar ( ortholog_one2one ) Rabbit_ ADAR ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | TARBP2, ADAT1, ADARB2, PRKRA, ILF3, STRBP, ZFR, ADAD1, ADARB1, STAU2, ILF2, ZFR2, STAU1, ADAD2 |
| Tissue | NA |
| Tissue Specificity | Ubiquitously expressed, highest levels were found in brain and lung (PubMed:7972084). Isoform 5 is expressed at higher levels in astrocytomas as compared to normal brain tissue and expression increases strikingly with the severity of the tumor, being higher in the most aggressive tumors. {ECO:0000269|PubMed:18178553, ECO:0000269|PubMed:7972084}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1QBJ (X-ray 2.10A ) 1QGP (NMR - ) 1XMK (X-ray 0.97A ) 2ACJ (X-ray 2.60A ) 2GXB (X-ray 2.25A ) 2L54 (NMR - ) 2MDR (NMR - ) 3F21 (X-ray 2.20A ) 3F22 (X-ray 2.50A ) 3F23 (X-ray 2.70A ) 3IRQ (X-ray 2.80A ) 3IRR (X-ray 2.65A ) 5ZU1 (X-ray 3.01A ) 5ZUO (X-ray 2.90A ) 5ZUP (X-ray 2.90A ) 7C0I (X-ray 2.40A ) |
| DBSNP | rs1466731 rs145588689 rs2229857 rs17843865 rs144119808 rs398122893 rs398122897 rs398122892 rs28936680 rs398122896 rs398122822 rs398122895 rs398122894 rs1044845711 rs28936681 |
| Subcellular location [CC] | [Isoform 1]: Cytoplasm {ECO:0000269|PubMed:7565688}. Nucleus {ECO:0000269|PubMed:24753571, ECO:0000269|PubMed:7565688}. Note=Shuttles between the cytoplasm and nucleus (PubMed:7565688, PubMed:24753571). Nuclear import is mediated by TNPO1 (PubMed:24753571). {ECO:0000269|PubMed:24753571, ECO:0000269|PubMed:7565688}.; [Isoform 5]: Cytoplasm {ECO:0000269|PubMed:19124606}. Nucleus {ECO:0000269|PubMed:19124606, ECO:0000269|PubMed:7565688}. Nucleus, nucleolus {ECO:0000269|PubMed:12665561}. Note=Predominantly nuclear but can shuttle between nucleus and cytoplasm. TNPO1 can mediate its nuclear import whereas XPO5 can mediate its nuclear export. {ECO:0000269|PubMed:19124606}. |
| Mouse PG classification | LPG |
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