| Gene Information | |
|---|---|
| Gene Name | LCLAT1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 414 |
| Protein Names | Lysocardiolipin acyltransferase 1 (EC 2.3.1.-) (1-acylglycerol-3-phosphate O-acyltransferase 8) (1-AGP acyltransferase 8) (1-AGPAT 8) (EC 2.3.1.51) (Acyl-CoA:lysocardiolipin acyltransferase 1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 1488 ( ENSG00000172954 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | Q6UWP7 |
| Gene Card | LCLAT1 |
| Uniprot ID | Q6UWP7 |
| Pfam | PF16076; PF01553 |
| In ASD | no |
| Allosteric Prediction | no (-0.891496826) |
| Ortholog in Animals | Alpaca_ LCLAT1 ( ortholog_one2one ) Dog_ LCLAT1 ( ortholog_one2one ) GuineaPig_ LCLAT1 ( ortholog_one2one ) Macaque_ LCLAT1 ( ortholog_one2one ) Mouse_ Lclat1 ( ortholog_one2one ) Pig_ LCLAT1 ( ortholog_one2one ) Rat_ Lclat1 ( ortholog_one2one ) Rabbit_ LCLAT1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | AGPAT4, AGPAT5, AGPAT3, LPGAT1 |
| Tissue | NA |
| Tissue Specificity | Expressed at higher level in heart, kidney and pancreas than in brain, spleen, liver, lung, small intestine and placenta. {ECO:0000269|PubMed:16620771, ECO:0000269|PubMed:19075029}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs12471868 |
| Subcellular location [CC] | Endoplasmic reticulum membrane {ECO:0000269|PubMed:19075029}; Multi-pass membrane protein {ECO:0000255}. |
| Mouse PG classification | NA |
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