| Gene Information | |
|---|---|
| Gene Name | SCO1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 301 |
| Protein Names | Protein SCO1 homolog, mitochondrial |
| Target Name | protein sco1 homolog, mitochondrial |
| Target Type | NA |
| Gene Age | 1714 ( ENSG00000133028 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | O75880 |
| Gene Card | SCO1 |
| Uniprot ID | O75880 |
| Pfam | PF02630 |
| In ASD | no |
| Allosteric Prediction | no (-0.760773534) |
| Ortholog in Animals | Alpaca_ SCO1 ( ortholog_one2one ) Dog_ SCO1 ( ortholog_one2one ) Macaque_ SCO1 ( ortholog_one2many ) Mouse_ Sco1 ( ortholog_one2one ) Pig_ SCO1 ( ortholog_one2one ) Rat_ Sco1 ( ortholog_one2one ) Rabbit_ SCO1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | SCO2 |
| Tissue | NA |
| Tissue Specificity | Predominantly expressed in tissues characterized by high rates of oxidative phosphorylation (OxPhos), including muscle, heart, and brain. {ECO:0000269|PubMed:9878253}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.018182(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
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| PDB | 1WP0 (X-ray 2.80A ) 2GGT (X-ray 2.40A ) 2GQK (NMR - ) 2GQL (NMR - ) 2GQM (NMR - ) 2GT5 (NMR - ) 2GT6 (NMR - ) 2GVP (NMR - ) 2HRF (NMR - ) 2HRN (NMR - ) |
| DBSNP | rs1802083 rs104894630 |
| Subcellular location [CC] | Mitochondrion {ECO:0000269|PubMed:9878253}. Mitochondrion inner membrane {ECO:0000269|PubMed:15229189}; Single-pass membrane protein {ECO:0000255}. |
| Mouse PG classification | NA |
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