Gene Information
Gene NameBID
OrganismHomo sapiens (Human)
Gene Length195
Protein NamesBH3-interacting domain death agonist (p22 BID) (BID) [Cleaved into: BH3-interacting domain death agonist p15 (p15 BID); BH3-interacting domain death agonist p13 (p13 BID); BH3-interacting domain death agonist p11 (p11 BID)]
Target NameNA
Target TypeNA
Gene Age424 ( ENSG00000015475 )
Evolutionary StageVertebrata
AlphaFoldDBP55957
Gene CardBID
Uniprot IDP55957
PfamPF06393
In ASDno
Allosteric Predictionyes (0.584062522)
Ortholog in AnimalsAlpaca_ BID ( ortholog_one2one )
Dog_ BID ( ortholog_one2many )
GuineaPig_ BID ( ortholog_one2one )
Macaque_ BID ( ortholog_one2one )
Mouse_ Bid ( ortholog_one2one )
Pig_ BID ( ortholog_one2one )
Rat_ Bid ( ortholog_one2one )
Rabbit_ BID ( ortholog_one2one )
OhnologsNA
ParalogsNA
TissueNA
Tissue Specificity[Isoform 2]: Expressed in spleen, pancreas and placenta (at protein level). {ECO:0000269|PubMed:14583606}.;
[Isoform 3]: Expressed in lung, pancreas and spleen (at protein level). {ECO:0000269|PubMed:14583606}.;
[Isoform 4]: Expressed in lung and pancreas (at protein level). {ECO:0000269|PubMed:14583606}.
Pharmacological Animal Models0.142124(Chimpanzee);0.023983(Mouse);NULL(Rat);0.126744(Rabbit)
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 1ZY3  (NMR  -  )  2BID  (NMR  -  )  2KBW  (NMR  -  )  2M5B  (NMR  -  )  2M5I  (NMR  -  )  4BD2  (X-ray  2.21A  )  4QVE  (X-ray  2.05A  )  4ZEQ  (X-ray  1.80A  )  4ZIG  (X-ray  2.20A  )  4ZII  (X-ray  2.19A  )  5AJJ  (X-ray  1.75A  )  5C3F  (X-ray  1.43A  )  7M5A  (X-ray  1.50A  )  7M5B  (X-ray  1.85A  )  7P33  (X-ray  2.79A  ) 
DBSNP rs8190315  rs17853595  rs59225839 
Subcellular location [CC]Cytoplasm {ECO:0000269|PubMed:14583606}. Mitochondrion membrane {ECO:0000269|PubMed:14583606}. Mitochondrion outer membrane {ECO:0000269|PubMed:29531808}. Note=When uncleaved, it is predominantly cytoplasmic. {ECO:0000269|PubMed:14583606}.;
[BH3-interacting domain death agonist p15]: Mitochondrion membrane {ECO:0000250|UniProtKB:P70444}. Note=Translocates to mitochondria as an integral membrane protein. {ECO:0000250|UniProtKB:P70444}.;
[BH3-interacting domain death agonist p13]: Mitochondrion membrane {ECO:0000250|UniProtKB:P70444}. Note=Associated with the mitochondrial membrane. {ECO:0000250|UniProtKB:P70444}.;
[Isoform 1]: Cytoplasm {ECO:0000269|PubMed:14583606}.;
[Isoform 3]: Cytoplasm {ECO:0000269|PubMed:14583606}.;
[Isoform 2]: Mitochondrion membrane {ECO:0000269|PubMed:14583606}. Note=A significant proportion of isoform 2 localizes to mitochondria, it may be cleaved constitutively. {ECO:0000269|PubMed:14583606}.
Mouse PG classificationNA
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