| Gene Information | |
|---|---|
| Gene Name | INSIG1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 277 |
| Protein Names | Insulin-induced gene 1 protein (INSIG-1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000186480 ) |
| Evolutionary Stage | Opisthokonta |
| AlphaFoldDB | O15503 |
| Gene Card | INSIG1 |
| Uniprot ID | O15503 |
| Pfam | PF07281 |
| In ASD | no |
| Allosteric Prediction | no (-0.181104871) |
| Ortholog in Animals | Alpaca_ INSIG1 ( ortholog_one2one ) Dog_ INSIG1 ( ortholog_one2one ) GuineaPig_ INSIG1 ( ortholog_one2one ) Macaque_ INSIG1 ( ortholog_one2one ) Mouse_ Insig1 ( ortholog_one2one ) Pig_ INSIG1 ( ortholog_one2one ) Rat_ AABR07060293.1 ( ortholog_one2many ) Rat_ Insig1 ( ortholog_one2many ) Rabbit_ INSIG1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | INSIG2 |
| Tissue | NA |
| Tissue Specificity | Expressed in all tissues tested with highest expression in the liver. {ECO:0000269|PubMed:12202038}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.002240(Rat);0.05(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 4J81 (X-ray 1.74A ) |
| DBSNP | rs1129825 |
| Subcellular location [CC] | Endoplasmic reticulum membrane {ECO:0000269|PubMed:12202038, ECO:0000269|PubMed:32322062}; Multi-pass membrane protein {ECO:0000269|PubMed:12202038}. |
| Mouse PG classification | NA |
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