| Gene Information | |
|---|---|
| Gene Name | GZMM |
| Organism | Homo sapiens (Human) |
| Gene Length | 257 |
| Protein Names | Granzyme M (EC 3.4.21.-) (Met-1 serine protease) (Hu-Met-1) (Met-ase) (Natural killer cell granular protease) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 55 ( ENSG00000197540 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | P51124 |
| Gene Card | GZMM |
| Uniprot ID | P51124 |
| Pfam | PF00089 |
| In ASD | no |
| Allosteric Prediction | no (-0.608214173) |
| Ortholog in Animals | Alpaca_ GZMM ( ortholog_one2one ) Macaque_ GZMM ( ortholog_one2one ) Mouse_ Gzmm ( ortholog_one2one ) Pig_ GZMM ( ortholog_one2one ) Rat_ Gzmm ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | OVCH1, PLAT, PRSS48, PLGLB1, PLGLB2, PLG, TMPRSS12, KLK15, PRSS37, PRSS27, PRSS33, PRSS57, PRSS50, KLK9 |
| Tissue | appendix, lymph.node, spleen, whole.blood |
| Tissue Specificity | Highly and constitutively expressed in activated natural killer (NK) cells. {ECO:0000269|PubMed:18523284}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2ZGC (X-ray 1.96A ) 2ZGH (X-ray 2.17A ) 2ZGJ (X-ray 2.30A ) 2ZKS (X-ray 2.70A ) |
| DBSNP | rs1599882 |
| Subcellular location [CC] | Secreted. Cytoplasmic granule. Note=Granules of large granular lymphocytes. |
| Mouse PG classification | NA |
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