| Gene Information | |
|---|---|
| Gene Name | PLEKHA2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 425 |
| Protein Names | Pleckstrin homology domain-containing family A member 2 (PH domain-containing family A member 2) (Tandem PH domain-containing protein 2) (TAPP-2) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 454 ( ENSG00000169499 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | Q9HB19 |
| Gene Card | PLEKHA2 |
| Uniprot ID | Q9HB19 |
| Pfam | PF00169 |
| In ASD | no |
| Allosteric Prediction | no (-0.735694478) |
| Ortholog in Animals | Alpaca_ PLEKHA2 ( ortholog_one2one ) Dog_ PLEKHA2 ( ortholog_one2one ) GuineaPig_ PLEKHA2 ( ortholog_one2one ) Macaque_ PLEKHA2 ( ortholog_one2one ) Mouse_ Plekha2 ( ortholog_one2one ) Pig_ PLEKHA2 ( ortholog_one2one ) Rat_ Plekha2 ( ortholog_one2one ) Rabbit_ PLEKHA2 ( ortholog_one2one ) |
| Ohnologs | PLEKHA1 |
| Paralogs | PLEKHA1 |
| Tissue | NA |
| Tissue Specificity | Highly expressed in heart, kidney, spleen and peripheral blood leukocytes. Detected at lower levels in brain, skeletal muscle, colon, thymus, liver, small intestine, placenta and lung. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs59439576 |
| Subcellular location [CC] | Cytoplasm {ECO:0000250}. Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Nucleus {ECO:0000250}. Note=Locates to the plasma membrane after treatments that stimulate the production of PtdIns3,4P2. {ECO:0000250}. |
| Mouse PG classification | NA |
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