| Gene Information | |
|---|---|
| Gene Name | HINT2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 163 |
| Protein Names | Adenosine 5'-monophosphoramidase HINT2 (EC 3.9.1.-) (HINT-3) (HIT-17kDa) (Histidine triad nucleotide-binding protein 2, mitochondrial) (HINT-2) (PKCI-1-related HIT protein) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 680 ( ENSG00000137133 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | Q9BX68 |
| Gene Card | HINT2 |
| Uniprot ID | Q9BX68 |
| Pfam | PF01230 |
| In ASD | no |
| Allosteric Prediction | no (-1.104182196) |
| Ortholog in Animals | Alpaca_ HINT2 ( ortholog_one2one ) Dog_ HINT2 ( ortholog_one2one ) GuineaPig_ HINT2 ( ortholog_one2one ) Macaque_ HINT2 ( ortholog_one2one ) Mouse_ Hint2 ( ortholog_one2one ) Rat_ Hint2 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | HINT1, FHIT |
| Tissue | NA |
| Tissue Specificity | High expression in liver and pancreas. Expression is significantly down-regulated in hepatocellular carcinoma (HCC) patients. {ECO:0000269|PubMed:16762638}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 4INC (X-ray 1.19A ) 4INI (X-ray 1.65A ) 5KM5 (X-ray 2.10A ) 5KM8 (X-ray 2.00A ) 5KM9 (X-ray 1.45A ) 6YI0 (X-ray 1.65A ) 6YPR (X-ray 1.26A ) 6YPX (X-ray 2.11A ) 6YQD (X-ray 1.41A ) 6YVP (X-ray 2.77A ) |
| DBSNP | NA |
| Subcellular location [CC] | Mitochondrion {ECO:0000269|PubMed:16762638, ECO:0000269|PubMed:18653718}. |
| Mouse PG classification | NA |
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