| Gene Information | |
|---|---|
| Gene Name | GUCY2F |
| Organism | Homo sapiens (Human) |
| Gene Length | 1108 |
| Protein Names | Retinal guanylyl cyclase 2 (RETGC-2) (EC 4.6.1.2) (Guanylate cyclase 2F, retinal) (Guanylate cyclase F) (GC-F) (Rod outer segment membrane guanylate cyclase 2) (ROS-GC2) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 987 ( ENSG00000101890 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | P51841 |
| Gene Card | GUCY2F |
| Uniprot ID | P51841 |
| Pfam | PF01094; PF00211; PF07701; PF07714 |
| In ASD | no |
| Allosteric Prediction | yes (0.838334575) |
| Ortholog in Animals | Alpaca_ GUCY2F ( ortholog_one2one ) Dog_ GUCY2F ( ortholog_one2one ) GuineaPig_ GUCY2F ( ortholog_one2one ) Macaque_ GUCY2F ( ortholog_one2one ) Mouse_ Gucy2f ( ortholog_one2one ) Rat_ Gucy2f ( ortholog_one2one ) Rabbit_ GUCY2F ( ortholog_one2one ) |
| Ohnologs | GUCY2D |
| Paralogs | ADCY8, GUCY1B1, ADCY7, NPR2, ADCY3, GUCY1A1, ADCY1, NPR1, ADCY9, ADCY6, GUCY2C, GUCY2D, GUCY1A2, ADCY4, ADCY5, ADCY2, NPR3 |
| Tissue | NA |
| Tissue Specificity | Retina. Localized exclusively in the outer nuclear layer and inner segments of the rod and cone photoreceptor cells. {ECO:0000269|PubMed:7777544}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001000(Rat);0.04(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs755991142 rs34228145 rs33971675 rs33973457 rs12008095 rs502209 rs55966326 rs16985750 rs2272925 rs56293008 rs779221554 rs7883913 rs35474112 rs35726803 rs148663380 rs55735218 |
| Subcellular location [CC] | Photoreceptor outer segment membrane {ECO:0000250|UniProtKB:O02740}; Single-pass type I membrane protein {ECO:0000255}. |
| Mouse PG classification | NA |
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