| Gene Information | |
|---|---|
| Gene Name | GUCY2C |
| Organism | Homo sapiens (Human) |
| Gene Length | 1073 |
| Protein Names | Guanylyl cyclase C (GC-C) (EC 4.6.1.2) (Heat-stable enterotoxin receptor) (STA receptor) (hSTAR) (Intestinal guanylate cyclase) |
| Target Name | guanylyl cyclase c |
| Target Type | Successful target |
| Gene Age | 987 ( ENSG00000070019 ) |
| Evolutionary Stage | Opisthokonta |
| AlphaFoldDB | P25092 |
| Gene Card | GUCY2C |
| Uniprot ID | P25092 |
| Pfam | PF00211; PF07714 |
| In ASD | yes |
| Allosteric Prediction | yes (1.149535113) |
| Ortholog in Animals | Alpaca_ GUCY2C ( ortholog_one2one ) Dog_ GUCY2C ( ortholog_one2one ) GuineaPig_ GUCY2C ( ortholog_one2one ) Macaque_ GUCY2C ( ortholog_one2one ) Mouse_ Gucy2c ( ortholog_one2one ) Pig_ GUCY2C ( ortholog_one2one ) Rat_ Gucy2c ( ortholog_one2one ) Rabbit_ GUCY2C ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | ADCY8, GUCY1B1, ADCY7, NPR2, ADCY3, GUCY1A1, ADCY1, NPR1, ADCY9, ADCY6, GUCY2D, GUCY1A2, ADCY4, ADCY5, ADCY2, GUCY2F, NPR3 |
| Tissue | colon, duodenum, small.intestine, rectum, small.intestine.Peyers.patch, transverse.colon |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs56142849 rs56275235 rs1420635 rs587776905 rs55684775 rs55897626 rs587776871 rs34890806 rs35617837 rs35179392 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:23269669}; Single-pass type I membrane protein {ECO:0000269|PubMed:23269669}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:23269669}; Single-pass type I membrane protein {ECO:0000269|PubMed:23269669}. Note=The 145 kDa plasma membrane form of GUCY2C contains sialic acid and galactose residues, while a differencially glycosylated 130 Kda form is a high mannose form that is resident in the endoplasmic reticulum and may serve as the precursor for the cell surface form. {ECO:0000269|PubMed:23269669}. |
| Mouse PG classification | HPG |
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