| Gene Information | |
|---|---|
| Gene Name | GUCY1B1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 619 |
| Protein Names | Guanylate cyclase soluble subunit beta-1 (GCS-beta-1) (EC 4.6.1.2) (Guanylate cyclase soluble subunit beta-3) (GCS-beta-3) (Soluble guanylate cyclase small subunit) |
| Target Name | guanylate cyclase soluble beta-1 |
| Target Type | Clinical trial target |
| Gene Age | 950 ( ENSG00000061918 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q02153 |
| Gene Card | GUCY1B1 |
| Uniprot ID | Q02153 |
| Pfam | PF00211; PF07700; PF07701 |
| In ASD | yes |
| Allosteric Prediction | yes (0.572782439) |
| Ortholog in Animals | Alpaca_ GUCY1B1 ( ortholog_one2one ) Dog_ GUCY1B1 ( ortholog_one2one ) GuineaPig_ GUCY1B1 ( ortholog_one2one ) Macaque_ GUCY1B1 ( ortholog_one2one ) Mouse_ Gucy1b1 ( ortholog_one2one ) Pig_ GUCY1B1 ( ortholog_one2one ) Rat_ Gucy1b1 ( ortholog_one2one ) Rabbit_ GUCY1B1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | ADCY8, ADCY7, NPR2, ADCY3, GUCY1A1, ADCY1, NPR1, ADCY9, ADCY6, GUCY2C, GUCY2D, GUCY1A2, ADCY4, ADCY5, ADCY2, GUCY2F, NPR3 |
| Tissue | NA |
| Tissue Specificity | Detected in brain cortex and cerebellum (at protein level). {ECO:0000269|PubMed:1352257}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.002657(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 2WZ1 (X-ray 1.63A ) 3UVJ (X-ray 2.08A ) 4NI2 (X-ray 1.90A ) 5MNW (NMR - ) 6JT0 (EM 4.00A ) 6JT1 (EM 3.90A ) 6JT2 (EM 3.80A ) 7D9R (EM 3.30A ) 7D9S (EM 3.40A ) 7D9T (EM 4.10A ) 7D9U (EM 3.80A ) |
| DBSNP | NA |
| Subcellular location [CC] | Cytoplasm {ECO:0000250|UniProtKB:P16068}. |
| Mouse PG classification | NA |
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