Gene Information
Gene NameALOX15
OrganismHomo sapiens (Human)
Gene Length662
Protein NamesPolyunsaturated fatty acid lipoxygenase ALOX15 (12/15-lipoxygenase) (Arachidonate 12-lipoxygenase, leukocyte-type) (12-LOX) (EC 1.13.11.31) (Arachidonate 15-lipoxygenase) (15-LOX) (15-LOX-1) (EC 1.13.11.33) (Arachidonate omega-6 lipoxygenase) (Hepoxilin A3 synthase Alox15) (EC 1.13.11.-) (Linoleate 13S-lipoxygenase) (EC 1.13.11.12)
Target Namearachidonate 15-lipoxygenase
Target TypeNA
Gene Age987 ( ENSG00000161905 )
Evolutionary StageEuk+Bac
AlphaFoldDBP16050
Gene CardALOX15
Uniprot IDP16050
PfamPF00305; PF01477
In ASDyes
Allosteric Predictionyes (0.999695565)
Ortholog in AnimalsAlpaca_ ALOX15 ( ortholog_one2one )
Dog_ ALOX15 ( ortholog_one2one )
Macaque_ ALOX15 ( ortholog_one2one )
Mouse_ Alox15 ( ortholog_one2one )
Pig_ ALOX15 ( ortholog_one2one )
Rat_ Alox15 ( ortholog_one2one )
Rabbit_ ALOX15 ( ortholog_one2one )
OhnologsALOXE3, ALOX12B
ParalogsALOX12, ALOXE3, ALOX5, ALOX15B, ALOX12B
TissueNA
Tissue SpecificityDetected in monocytes and eosinophils (at protein level). Expressed in airway epithelial cells. {ECO:0000269|PubMed:21831839, ECO:0000269|PubMed:9414270}.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB NA 
DBSNP rs11568142  rs41439950  rs11568099  rs11568101  rs3892408  rs17852628  rs34210653 
Subcellular location [CC]Cytoplasm, cytosol {ECO:0000269|PubMed:17052953, ECO:0000269|PubMed:21831839}. Cell membrane {ECO:0000269|PubMed:21831839};
Peripheral membrane protein {ECO:0000269|PubMed:17052953}. Lipid droplet {ECO:0000269|PubMed:19528634}. Note=Predominantly cytosolic;
becomes enriched at membranes upon calcium binding (By similarity). Translocates from the cytosol to the plasma membrane when stimulated by IL13/interleukin-13 and in macrophages binding apoptotic cells (By similarity). {ECO:0000250|UniProtKB:P39654}.
Mouse PG classificationNA
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