| Gene Information | |
|---|---|
| Gene Name | GUCA2A |
| Organism | Homo sapiens (Human) |
| Gene Length | 115 |
| Protein Names | Guanylin (Guanylate cyclase activator 2A) (Guanylate cyclase-activating protein 1) (Guanylate cyclase-activating protein I) (GCAP-I) [Cleaved into: HMW-guanylin; Guanylin] |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 168 ( ENSG00000197273 ) |
| Evolutionary Stage | Mammalia |
| AlphaFoldDB | Q02747 |
| Gene Card | GUCA2A |
| Uniprot ID | Q02747 |
| Pfam | PF02058 |
| In ASD | no |
| Allosteric Prediction | no (-0.333866118) |
| Ortholog in Animals | Alpaca_ GUCA2A ( ortholog_one2one ) Dog_ GUCA2A ( ortholog_one2one ) GuineaPig_ GUCA2A ( ortholog_one2one ) Macaque_ GUCA2A ( ortholog_one2one ) Mouse_ Guca2a ( ortholog_one2one ) Pig_ GUCA2A ( ortholog_one2one ) Rat_ Guca2a ( ortholog_one2one ) Rabbit_ GUCA2A ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | GUCA2B |
| Tissue | small.intestine, colon, rectum, sigmoid.colon, small.intestine.Peyers.patch |
| Tissue Specificity | Highly expressed in ileum and colon. Found in plasma. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1GNA (NMR - ) 1GNB (NMR - ) 1O8R (NMR - ) |
| DBSNP | rs2071499 |
| Subcellular location [CC] | Secreted. |
| Mouse PG classification | NA |
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