| Gene Information | |
|---|---|
| Gene Name | GUCA1A |
| Organism | Homo sapiens (Human) |
| Gene Length | 201 |
| Protein Names | Guanylyl cyclase-activating protein 1 (GCAP 1) (Guanylate cyclase activator 1A) |
| Target Name | guanylyl cyclase-activating protein 1 |
| Target Type | NA |
| Gene Age | 1488 ( ENSG00000048545 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | P43080 |
| Gene Card | GUCA1A |
| Uniprot ID | P43080 |
| Pfam | PF13499; PF13833 |
| In ASD | yes |
| Allosteric Prediction | yes (0.50120831) |
| Ortholog in Animals | Alpaca_ GUCA1A ( ortholog_one2one ) Dog_ GUCA1A ( ortholog_one2one ) GuineaPig_ GUCA1A ( ortholog_one2one ) Macaque_ GUCA1A ( ortholog_one2one ) Mouse_ Guca1a ( ortholog_one2one ) Pig_ GUCA1A ( ortholog_one2one ) Rat_ Guca1a ( ortholog_one2one ) Rabbit_ GUCA1A ( ortholog_one2one ) |
| Ohnologs | GUCA1C |
| Paralogs | KCNIP4, KCNIP2, GUCA1B, VSNL1, KCNIP1, HPCAL1, NCS1, KCNIP3, GUCA1C, RCVRN, CLXN, NCALD, HPCAL4, HPCA |
| Tissue | testis, pineal.gland |
| Tissue Specificity | In the retina, it is expressed in rod and cone photoreceptors. {ECO:0000269|PubMed:9620085}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | NA |
| DBSNP | rs104893968 rs104893967 rs771261841 rs121434631 |
| Subcellular location [CC] | Membrane; Lipid-anchor {ECO:0000250|UniProtKB:P46065}. Photoreceptor inner segment {ECO:0000269|PubMed:9620085}. Cell projection, cilium, photoreceptor outer segment {ECO:0000269|PubMed:9620085}. Note=Present at higher levels in cone than in rod outer segments (PubMed:9620085). Subcellular location is not affected by light or dark conditions. {ECO:0000269|PubMed:9620085}. |
| Mouse PG classification | HPG |
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