| Gene Information | |
|---|---|
| Gene Name | SERINC3 |
| Organism | Homo sapiens (Human) |
| Gene Length | 473 |
| Protein Names | Serine incorporator 3 (Tumor differentially expressed protein 1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 1714 ( ENSG00000132824 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q13530 |
| Gene Card | SERINC3 |
| Uniprot ID | Q13530 |
| Pfam | PF03348 |
| In ASD | no |
| Allosteric Prediction | no (-0.038999092) |
| Ortholog in Animals | Alpaca_ SERINC3 ( ortholog_one2one ) Dog_ SERINC3 ( ortholog_one2one ) GuineaPig_ SERINC3 ( ortholog_one2one ) Macaque_ SERINC3 ( ortholog_one2one ) Mouse_ Serinc3 ( ortholog_one2one ) Pig_ SERINC3 ( ortholog_one2one ) Rat_ Serinc3 ( ortholog_one2one ) Rabbit_ SERINC3 ( ortholog_one2one ) |
| Ohnologs | SERINC1, SERINC2 |
| Paralogs | SERINC1, SERINC2, SERINC4, SERINC5 |
| Tissue | NA |
| Tissue Specificity | Ubiquitous. Expression levels were increased fourfold to tenfold in lung tumor tissues compared with normal pulmonary tissues. {ECO:0000269|PubMed:10559794}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 7RU6 (EM 4.40A ) 7RUG (EM 4.70A ) |
| DBSNP | NA |
| Subcellular location [CC] | Cell membrane {ECO:0000250|UniProtKB:Q86VE9}; Multi-pass membrane protein {ECO:0000255}. Golgi apparatus membrane {ECO:0000250|UniProtKB:Q9QZI9}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q9QZI9}.; Cytoplasm, perinuclear region {ECO:0000305|PubMed:26416734}. Note=(Microbial infection) Upon HIV-1 infection, it is redirected to perinuclear region following interaction with HIV-1 Nef, excluding it from virions particles, thereby preventing subsequent antiviral defense activity (Probable). {ECO:0000305|PubMed:26416734}. |
| Mouse PG classification | NA |
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