| Gene Information | |
|---|---|
| Gene Name | CPN1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 537 |
| Protein Names | Copine-1 (Chromobindin 17) (Copine I) |
| Target Name | carboxypeptidase n catalytic chain |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000120054 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | Q99829 |
| Gene Card | CPNE1 |
| Uniprot ID | Q99829 |
| Pfam | PF00168; PF07002 |
| In ASD | no |
| Allosteric Prediction | yes (0.447858804) |
| Ortholog in Animals | Alpaca_ CPN1 ( ortholog_one2one ) Dog_ CPN1 ( ortholog_one2one ) GuineaPig_ CPN1 ( ortholog_one2one ) Macaque_ CPN1 ( ortholog_one2one ) Mouse_ Cpn1 ( ortholog_one2one ) Pig_ CPN1 ( ortholog_one2one ) Rat_ Cpn1 ( ortholog_one2one ) Rabbit_ CPN1 ( ortholog_one2one ) |
| Ohnologs | CPXM1, CPE, CPZ |
| Paralogs | CPXM2, CPD, AEBP1, CPXM1, CPM, CPE, CPZ |
| Tissue | liver |
| Tissue Specificity | Expressed in neutrophils (at protein level) (PubMed:12949241). Widely expressed. Expressed in the brain. Expressed in neutrophil precursors from bone marrow and peripheral blood (PubMed:12949241). {ECO:0000269|PubMed:12949241}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs6579255 rs12481228 rs11543239 |
| Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:18212740, ECO:0000269|PubMed:21087455}. Cytoplasm {ECO:0000269|PubMed:12949241, ECO:0000269|PubMed:18212740, ECO:0000269|PubMed:21087455, ECO:0000269|PubMed:25450385}. Cell membrane {ECO:0000269|PubMed:21087455, ECO:0000269|PubMed:25450385}. Note=Translocates to the cell membrane in a calcium-dependent manner (PubMed:21087455, PubMed:25450385). {ECO:0000269|PubMed:21087455, ECO:0000269|PubMed:25450385}. |
| Mouse PG classification | NA |
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