| Gene Information | |
|---|---|
| Gene Name | SLC38A2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 506 |
| Protein Names | Sodium-coupled neutral amino acid symporter 2 (Amino acid transporter A2) (Protein 40-9-1) (Solute carrier family 38 member 2) (System A amino acid transporter 2) (System A transporter 1) (System N amino acid transporter 2) |
| Target Name | sodium-coupled neutral amino acid transporters |
| Target Type | NA |
| Gene Age | 1488 ( ENSG00000134294 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q96QD8 |
| Gene Card | SLC38A2 |
| Uniprot ID | Q96QD8 |
| Pfam | PF01490 |
| In ASD | no |
| Allosteric Prediction | no (-0.244552464) |
| Ortholog in Animals | Alpaca_ SLC38A2 ( ortholog_one2one ) Dog_ SLC38A2 ( ortholog_one2one ) GuineaPig_ SLC38A2 ( ortholog_one2one ) Macaque_ SLC38A2 ( ortholog_one2one ) Mouse_ Slc38a2 ( ortholog_one2one ) Pig_ SLC38A2 ( ortholog_one2one ) Rat_ Slc38a2 ( ortholog_one2one ) Rabbit_ SLC38A2 ( ortholog_one2one ) |
| Ohnologs | SLC38A5, SLC38A8, SLC38A3 |
| Paralogs | SLC38A3, SLC36A1, SLC36A4, SLC38A10, SLC38A9, SLC36A3, SLC38A7, SLC38A8, SLC36A2, SLC38A4, SLC38A11, SLC38A6, SLC32A1, SLC38A1, SLC38A5 |
| Tissue | NA |
| Tissue Specificity | Ubiquitously expressed (PubMed:10930503). Expressed in neocortex (PubMed:16616430). Widely expressed in the central nervous system with higher concentrations in caudal regions. Expressed by glutamatergic and GABAergic neurons together with astrocytes and other non-neuronal cells in the cerebral cortex (at protein level) (PubMed:15774260). {ECO:0000269|PubMed:10930503, ECO:0000269|PubMed:15774260, ECO:0000269|PubMed:16616430}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | NA |
| DBSNP | rs11183450 |
| Subcellular location [CC] | Cell membrane {ECO:0000250|UniProtKB:Q9JHE5}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q9JHE5}. Note=Insulin promotes recruitment to the plasma membrane from a pool localized in the trans-Golgi network or endosomes. Enriched in the somatodendritic compartment of neurons, it is also detected at the axonal shaft but excluded from the nerve terminal. {ECO:0000250|UniProtKB:Q9JHE5}. |
| Mouse PG classification | NA |
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