| Gene Information | |
|---|---|
| Gene Name | GTF2H2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 395 |
| Protein Names | General transcription factor IIH subunit 2 (Basic transcription factor 2 44 kDa subunit) (BTF2 p44) (General transcription factor IIH polypeptide 2) (TFIIH basal transcription factor complex p44 subunit) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | >4290 ( ENSG00000145736 ) 3 ( ENSG00000275045 ) 3 ( ENSG00000276910 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q13888 |
| Gene Card | GTF2H2 |
| Uniprot ID | Q13888 |
| Pfam | PF07975; PF04056 |
| In ASD | no |
| Allosteric Prediction | yes (0.386921031) |
| Ortholog in Animals | Dog_ GTF2H2 ( ortholog_one2many ) Mouse_ Gtf2h2 ( ortholog_one2many ) Rat_ Gtf2h2 ( ortholog_one2many ) |
| Ohnologs | NA |
| Paralogs | GTF2H2C |
| Tissue | NA |
| Tissue Specificity | Widely expressed, with higher expression in skeletal muscle. {ECO:0000269|PubMed:9063743}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.057143(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1Z60 (NMR - ) 5IVW (EM 10.00A ) 5IY6 (EM 7.20A ) 5IY7 (EM 8.60A ) 5IY8 (EM 7.90A ) 5IY9 (EM 6.30A ) 5O85 (X-ray 3.40A ) 5OF4 (EM 4.40A ) 6NMI (EM 3.70A ) 6O9L (EM 7.20A ) 6O9M (EM 4.40A ) 6RO4 (EM 3.50A ) 7AD8 (EM 3.50A ) 7EGB (EM 3.30A ) 7EGC (EM 3.90A ) 7ENA (EM 4.07A ) 7ENC (EM 4.13A ) 7LBM (EM 4.80A ) 7NVR (EM 4.50A ) 7NVW (EM 4.30A ) 7NVX (EM 3.90A ) 7NVY (EM 7.30A ) 7NVZ (EM 7.20A ) 7NW0 (EM 6.60A ) |
| DBSNP | rs2576895 rs201102513 |
| Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:27193682}. |
| Mouse PG classification | NA |
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