| Gene Information | |
|---|---|
| Gene Name | GSTP1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 210 |
| Protein Names | Glutathione S-transferase P (EC 2.5.1.18) (GST class-pi) (GSTP1-1) |
| Target Name | glutathione s-transferase p |
| Target Type | Clinical trial target |
| Gene Age | 987 ( ENSG00000084207 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | P09211 |
| Gene Card | GSTP1 |
| Uniprot ID | P09211 |
| Pfam | PF14497; PF02798 |
| In ASD | yes |
| Allosteric Prediction | yes (0.999657216) |
| Ortholog in Animals | Alpaca_ GSTP1 ( ortholog_one2one ) GuineaPig_ GSTP1 ( ortholog_one2one ) Macaque_ GSTP1 ( ortholog_one2one ) Mouse_ Gstp1 ( ortholog_one2many ) Mouse_ Gstp2 ( ortholog_one2many ) Rat_ Gstp1 ( ortholog_one2many ) |
| Ohnologs | NA |
| Paralogs | GSTM1, GSTM3, GSTA5, GSTA4, GSTM2, GSTM5, GSTM4, GSTA1, GSTA2, HPGDS, GSTA3 |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.046038(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
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| PDB | 10GS (X-ray 2.20A ) 11GS (X-ray 2.30A ) 12GS (X-ray 2.10A ) 13GS (X-ray 1.90A ) 14GS (X-ray 2.80A ) 16GS (X-ray 1.90A ) 17GS (X-ray 1.90A ) 18GS (X-ray 1.90A ) 19GS (X-ray 1.90A ) 1AQV (X-ray 1.94A ) 1AQW (X-ray 1.80A ) 1AQX (X-ray 2.00A ) 1EOG (X-ray 2.10A ) 1EOH (X-ray 2.50A ) 1GSS (X-ray 2.80A ) 1KBN (X-ray 2.00A ) 1LBK (X-ray 1.86A ) 1MD3 (X-ray 2.03A ) 1MD4 (X-ray 2.10A ) 1PGT (X-ray 1.80A ) 1PX6 (X-ray 2.10A ) 1PX7 (X-ray 2.03A ) 1ZGN (X-ray 2.10A ) 20GS (X-ray 2.45A ) 22GS (X-ray 1.90A ) 2A2R (X-ray 1.40A ) 2A2S (X-ray 1.70A ) 2GSS (X-ray 1.90A ) 2J9H (X-ray 2.40A ) 2PGT (X-ray 1.90A ) 3CSH (X-ray 1.55A ) 3CSI (X-ray 1.90A ) 3CSJ (X-ray 1.90A ) 3DD3 (X-ray 2.25A ) 3DGQ (X-ray 1.60A ) 3GSS (X-ray 1.90A ) 3GUS (X-ray 1.53A ) 3HJM (X-ray 2.10A ) 3HJO (X-ray 1.95A ) 3HKR (X-ray 1.80A ) 3IE3 (X-ray 1.80A ) 3KM6 (X-ray 2.10A ) 3KMN (X-ray 1.80A ) 3KMO (X-ray 2.60A ) 3N9J (X-ray 1.85A ) 3PGT (X-ray 2.14A ) 4GSS (X-ray 2.50A ) 4PGT (X-ray 2.10A ) 5DAK (X-ray 2.11A ) 5DAL (X-ray 1.50A ) 5DCG (X-ray 2.01A ) 5DDL (X-ray 1.98A ) 5DJL (X-ray 1.80A ) 5DJM (X-ray 1.90A ) 5GSS (X-ray 1.95A ) 5J41 (X-ray 1.19A ) 5JCW (X-ray 1.95A ) 5L6X (X-ray 2.00A ) 5X79 (X-ray 1.90A ) 6AP9 (X-ray 1.55A ) 6GSS (X-ray 1.90A ) 6LLX (X-ray 1.58A ) 6Y1E (X-ray 1.40A ) 7BIA (X-ray 1.73A ) 7GSS (X-ray 2.20A ) 8GSS (X-ray 1.90A ) 9GSS (X-ray 1.97A ) |
| DBSNP | rs1695 rs1138272 rs41462048 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:19269317}. Mitochondrion {ECO:0000269|PubMed:19269317}. Nucleus {ECO:0000269|PubMed:19269317}. Note=The 83 N-terminal amino acids function as un uncleaved transit peptide, and arginine residues within it are crucial for mitochondrial localization. |
| Mouse PG classification | NA |
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