| Gene Information | |
|---|---|
| Gene Name | TDP1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 608 |
| Protein Names | Tyrosyl-DNA phosphodiesterase 1 (Tyr-DNA phosphodiesterase 1) (EC 3.1.4.-) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000042088 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q9NUW8 |
| Gene Card | TDP1 |
| Uniprot ID | Q9NUW8 |
| Pfam | PF06087 |
| In ASD | no |
| Allosteric Prediction | no (-0.138267307) |
| Ortholog in Animals | Alpaca_ TDP1 ( ortholog_one2one ) Dog_ TDP1 ( ortholog_one2one ) GuineaPig_ TDP1 ( ortholog_one2one ) Macaque_ TDP1 ( ortholog_one2one ) Mouse_ Tdp1 ( ortholog_one2one ) Pig_ TDP1 ( ortholog_one2one ) Rat_ Tdp1 ( ortholog_one2one ) Rabbit_ TDP1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Ubiquitously expressed. Similar expression throughout the central nervous system (whole brain, amygdala, caudate nucleus, cerebellum, cerebral cortex, frontal lobe, hippocampus, medulla oblongata, occipital lobe, putamen, substantia nigra, temporal lobe, thalamus, nucleus accumbens and spinal cord) and increased expression in testis and thymus. {ECO:0000269|PubMed:12244316, ECO:0000269|PubMed:17948061}. |
| Pharmacological Animal Models | NULL(Chimpanzee);0.044400(Mouse);NULL(Rat);0.018182(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 1JY1 (X-ray 1.69A ) 1MU7 (X-ray 2.00A ) 1MU9 (X-ray 2.05A ) 1NOP (X-ray 2.30A ) 1QZQ (X-ray 2.40A ) 1RFF (X-ray 1.70A ) 1RFI (X-ray 2.20A ) 1RG1 (X-ray 2.10A ) 1RG2 (X-ray 2.10A ) 1RGT (X-ray 2.00A ) 1RGU (X-ray 2.22A ) 1RH0 (X-ray 2.30A ) 5NW9 (X-ray 2.04A ) 5NWA (X-ray 3.20A ) 6DHU (X-ray 1.63A ) 6DIE (X-ray 1.78A ) 6DIH (X-ray 1.78A ) 6DIM (X-ray 1.81A ) 6DJD (X-ray 1.78A ) 6DJE (X-ray 1.71A ) 6DJF (X-ray 1.67A ) 6DJG (X-ray 1.88A ) 6DJH (X-ray 1.92A ) 6DJI (X-ray 1.75A ) 6DJJ (X-ray 1.74A ) 6MJ5 (X-ray 1.85A ) 6MYZ (X-ray 1.66A ) 6MZ0 (X-ray 1.97A ) 6N0D (X-ray 1.45A ) 6N0N (X-ray 1.48A ) 6N0O (X-ray 1.94A ) 6N0R (X-ray 1.54A ) 6N17 (X-ray 1.64A ) 6N19 (X-ray 1.50A ) 6W4R (X-ray 1.82A ) 6W7J (X-ray 1.49A ) 6W7K (X-ray 1.70A ) 6W7L (X-ray 1.86A ) |
| DBSNP | rs35114462 rs35455108 rs28365054 rs35271143 rs34452707 rs119467003 rs767298655 rs35973343 |
| Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:15647511}. Cytoplasm {ECO:0000269|PubMed:15647511}. |
| Mouse PG classification | LPG |
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