| Gene Information | |
|---|---|
| Gene Name | GSR |
| Organism | Homo sapiens (Human) |
| Gene Length | 522 |
| Protein Names | Glutathione reductase, mitochondrial (GR) (GRase) (EC 1.8.1.7) |
| Target Name | glutathione reductase |
| Target Type | Patented-recorded target |
| Gene Age | 1488 ( ENSG00000104687 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | P00390 |
| Gene Card | GSR |
| Uniprot ID | P00390 |
| Pfam | PF07992; PF02852 |
| In ASD | no |
| Allosteric Prediction | yes (1.146968857) |
| Ortholog in Animals | Alpaca_ GSR ( ortholog_one2one ) Dog_ GSR ( ortholog_one2one ) GuineaPig_ GSR ( ortholog_one2one ) Macaque_ GSR ( ortholog_one2one ) Mouse_ Gsr ( ortholog_one2one ) Pig_ GSR ( ortholog_one2one ) Rat_ Gsr ( ortholog_one2one ) Rabbit_ GSR ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | TXNRD3, AIFM3, AIFM1, PYROXD1, DLD, TXNRD2, TXNRD1 |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1ALG (NMR - ) 1BWC (X-ray 2.10A ) 1DNC (X-ray 1.70A ) 1GRA (X-ray 2.00A ) 1GRB (X-ray 1.85A ) 1GRE (X-ray 2.00A ) 1GRF (X-ray 2.00A ) 1GRG (X-ray 2.00A ) 1GRH (X-ray 3.00A ) 1GRT (X-ray 2.30A ) 1GSN (X-ray 1.70A ) 1K4Q (X-ray 1.90A ) 1XAN (X-ray 2.00A ) 2AAQ (X-ray 2.60A ) 2GH5 (X-ray 1.70A ) 2GRT (X-ray 2.70A ) 3DJG (X-ray 1.80A ) 3DJJ (X-ray 1.10A ) 3DK4 (X-ray 1.20A ) 3DK8 (X-ray 1.10A ) 3DK9 (X-ray 0.95A ) 3GRS (X-ray 1.54A ) 3GRT (X-ray 2.50A ) 3SQP (X-ray 2.21A ) 4GR1 (X-ray 2.40A ) 4GRT (X-ray 2.80A ) 5GRT (X-ray 2.40A ) |
| DBSNP | rs8190955 rs8190976 rs8190976 rs8190997 rs8191004 rs2020916 rs1586033745 |
| Subcellular location [CC] | [Isoform Mitochondrial]: Mitochondrion.; [Isoform Cytoplasmic]: Cytoplasm. |
| Mouse PG classification | NA |
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