Gene Information
Gene NameDCLK1
OrganismHomo sapiens (Human)
Gene Length740
Protein NamesSerine/threonine-protein kinase DCLK1 (EC 2.7.11.1) (Doublecortin domain-containing protein 3A) (Doublecortin-like and CAM kinase-like 1) (Doublecortin-like kinase 1)
Target Nameserine/threonine-protein kinase dclk1
Target TypeNA
Gene Age544 ( ENSG00000133083 )
Evolutionary StageEukaryota
AlphaFoldDBO15075
Gene CardDCLK1
Uniprot IDO15075
PfamPF03607; PF00069
In ASDno
Allosteric Predictionno (-0.426415011)
Ortholog in AnimalsAlpaca_ DCLK1 ( ortholog_one2one )
Dog_ DCLK1 ( ortholog_one2one )
GuineaPig_ DCLK1 ( ortholog_one2one )
Macaque_ DCLK1 ( ortholog_one2one )
Mouse_ Dclk1 ( ortholog_one2one )
Pig_ DCLK1 ( ortholog_one2one )
Rat_ Dclk1 ( ortholog_one2one )
Rabbit_ DCLK1 ( ortholog_one2one )
OhnologsDCX, DCLK2
ParalogsDCLK3, PHKG1, MYLK4, CAMKK1, CAMKK2, DCLK2, PSKH1, PNCK, CAMK1D, CAMKV, CAMK2B, CAMK1, STK11, STK33, PHKG2, PSKH2, CAMK2G, MYLK2, CAMK2D, CAMK2A, MYLK3, CAMK1G
Tissuecerebral.cortex
Tissue SpecificityIn fetal tissues, highly expressed in brain, detectable in lung and liver, but not in kidney. In adult tissues, expressed ubiquitously in the brain, detectable in the heart, liver, spleen, thymus, prostate, testis, ovary, small intestine and colon. The type A isoforms seem to be expressed predominantly in fetal brain whereas type B isoforms are expressed abundantly in both fetal and adult brain. {ECO:0000269|PubMed:10051403}.
Pharmacological Animal ModelsNULL(Chimpanzee);0.001000(Mouse);NULL(Rat);NULL(Rabbit)
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 1MFW  (X-ray  1.60A  )  1MG4  (X-ray  1.50A  )  1UF0  (NMR  -  )  5JZJ  (X-ray  1.71A  )  5JZN  (X-ray  2.85A  )  6KYQ  (X-ray  2.14A  )  6KYR  (X-ray  2.21A  )  7F3G  (X-ray  2.10A  )  7KX6  (X-ray  2.50A  )  7KX8  (X-ray  3.10A  )  7KXW  (X-ray  3.00A  ) 
DBSNP rs1366698690  rs56185003 
Subcellular location [CC]NA
Mouse PG classificationNA
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