| Gene Information | |
|---|---|
| Gene Name | GSN |
| Organism | Homo sapiens (Human) |
| Gene Length | 782 |
| Protein Names | Gelsolin (AGEL) (Actin-depolymerizing factor) (ADF) (Brevin) |
| Target Name | gelsolin |
| Target Type | NA |
| Gene Age | 1488 ( ENSG00000148180 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | P06396 |
| Gene Card | GSN |
| Uniprot ID | P06396 |
| Pfam | PF00626 |
| In ASD | no |
| Allosteric Prediction | yes (1.029652723) |
| Ortholog in Animals | Alpaca_ GSN ( ortholog_one2one ) Dog_ GSN ( ortholog_one2one ) GuineaPig_ GSN ( ortholog_one2one ) Macaque_ GSN ( ortholog_one2one ) Mouse_ Gsn ( ortholog_one2one ) Pig_ GSN ( ortholog_one2one ) Rat_ Gsn ( ortholog_one2one ) Rabbit_ GSN ( ortholog_one2one ) |
| Ohnologs | VIL1 |
| Paralogs | VIL1, VILL, SCIN, SVIL, CAPG, AVIL, FLII |
| Tissue | NA |
| Tissue Specificity | Phagocytic cells, platelets, fibroblasts, nonmuscle cells, smooth and skeletal muscle cells. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
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| PDB | 1C0F (X-ray 2.40A ) 1C0G (X-ray 2.00A ) 1D4X (X-ray 1.75A ) 1DEJ (X-ray 2.40A ) 1EQY (X-ray 2.30A ) 1ESV (X-ray 2.00A ) 1H1V (X-ray 3.00A ) 1KCQ (X-ray 1.65A ) 1MDU (X-ray 2.20A ) 1NLV (X-ray 1.80A ) 1NM1 (X-ray 1.80A ) 1NMD (X-ray 1.90A ) 1P8X (X-ray 2.00A ) 1P8Z (X-ray 2.60A ) 1SOL (NMR - ) 1T44 (X-ray 2.00A ) 1YAG (X-ray 1.90A ) 1YVN (X-ray 2.10A ) 2FF3 (X-ray 2.00A ) 2FF6 (X-ray 2.05A ) 2FH1 (X-ray 1.55A ) 2FH2 (X-ray 2.50A ) 2FH3 (X-ray 2.87A ) 2FH4 (X-ray 3.00A ) 3A5L (X-ray 2.40A ) 3A5M (X-ray 2.40A ) 3A5N (X-ray 2.36A ) 3A5O (X-ray 2.40A ) 3CI5 (X-ray 1.70A ) 3CIP (X-ray 1.60A ) 3CJB (X-ray 3.21A ) 3CJC (X-ray 3.90A ) 3FFK (X-ray 3.00A ) 3FFN (X-ray 3.00A ) 3TU5 (X-ray 3.00A ) 4PKG (X-ray 1.80A ) 4PKH (X-ray 2.15A ) 4PKI (X-ray 2.30A ) 4S10 (X-ray 2.61A ) 4Z94 (X-ray 2.40A ) 5DD2 5FAE (X-ray 1.70A ) 5FAF (X-ray 1.05A ) 5H3M (NMR - ) 5H3N (NMR - ) 5O2Z (X-ray 1.70A ) 5UBO (X-ray 2.39A ) 5ZZ0 (X-ray 2.63A ) 6H1F (X-ray 1.90A ) 6JCO (X-ray 2.88A ) 6JEG (X-ray 2.98A ) 6JEH (X-ray 2.95A ) 6LJE (X-ray 1.40A ) 6LJF (X-ray 1.50A ) 6Q9R (X-ray 2.73A ) 6Q9Z (X-ray 3.80A ) 6QBF (X-ray 3.50A ) 6QW3 (X-ray 1.30A ) 7P2B (X-ray 3.00A ) |
| DBSNP | rs2230287 rs121909715 rs121909715 rs11550199 rs9696578 |
| Subcellular location [CC] | [Isoform 2]: Cytoplasm, cytoskeleton.; [Isoform 1]: Secreted. |
| Mouse PG classification | LPG |
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