| Gene Information | |
|---|---|
| Gene Name | GSK3B |
| Organism | Homo sapiens (Human) |
| Gene Length | 420 |
| Protein Names | Glycogen synthase kinase-3 beta (GSK-3 beta) (EC 2.7.11.26) (Serine/threonine-protein kinase GSK3B) (EC 2.7.11.1) |
| Target Name | glycogen synthase kinase-3 beta |
| Target Type | Clinical trial target |
| Gene Age | >4290 ( ENSG00000082701 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | P49841 |
| Gene Card | GSK3B |
| Uniprot ID | P49841 |
| Pfam | PF00069 |
| In ASD | yes |
| Allosteric Prediction | yes (1.237855814) |
| Ortholog in Animals | Alpaca_ GSK3B ( ortholog_one2one ) Dog_ GSK3B ( ortholog_one2one ) GuineaPig_ GSK3B ( ortholog_one2one ) Macaque_ GSK3B ( ortholog_one2one ) Mouse_ Gsk3b ( ortholog_one2one ) Pig_ GSK3B ( ortholog_one2one ) Rat_ Gsk3b ( ortholog_one2one ) Rabbit_ GSK3B ( ortholog_one2one ) |
| Ohnologs | GSK3A |
| Paralogs | GSK3A |
| Tissue | NA |
| Tissue Specificity | Expressed in testis, thymus, prostate and ovary and weakly expressed in lung, brain and kidney. Colocalizes with EIF2AK2/PKR and TAU in the Alzheimer disease (AD) brain. {ECO:0000269|PubMed:21029237}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001546(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 1GNG (X-ray 2.60A ) 1H8F (X-ray 2.80A ) 1I09 (X-ray 2.70A ) 1J1B (X-ray 1.80A ) 1J1C (X-ray 2.10A ) 1O6K (X-ray 1.70A ) 1O6L (X-ray 1.60A ) 1O9U (X-ray 2.40A ) 1PYX (X-ray 2.40A ) 1Q3D (X-ray 2.20A ) 1Q3W (X-ray 2.30A ) 1Q41 (X-ray 2.10A ) 1Q4L (X-ray 2.77A ) 1Q5K (X-ray 1.94A ) 1R0E (X-ray 2.25A ) 1UV5 (X-ray 2.80A ) 2JDO (X-ray 1.80A ) 2JDR (X-ray 2.30A ) 2JLD (X-ray 2.35A ) 2O5K (X-ray 3.20A ) 2OW3 (X-ray 2.80A ) 2UW9 (X-ray 2.10A ) 2X39 (X-ray 1.93A ) 2XH5 (X-ray 2.72A ) 3CQU (X-ray 2.20A ) 3CQW (X-ray 2.00A ) 3DU8 (X-ray 2.20A ) 3E87 (X-ray 2.30A ) 3E88 (X-ray 2.50A ) 3E8D (X-ray 2.70A ) 3F7Z (X-ray 2.40A ) 3F88 (X-ray 2.60A ) 3GB2 (X-ray 2.40A ) 3I4B (X-ray 2.30A ) 3L1S (X-ray 2.90A ) 3M1S (X-ray 3.13A ) 3MV5 (X-ray 2.47A ) 3OW4 (X-ray 2.60A ) 3PUP (X-ray 2.99A ) 3Q3B (X-ray 2.70A ) 3QKK (X-ray 2.30A ) 3SAY (X-ray 2.23A ) 3SD0 (X-ray 2.70A ) 3ZDI (X-ray 2.64A ) 3ZRK (X-ray 2.37A ) 3ZRL (X-ray 2.48A ) 3ZRM (X-ray 2.49A ) 4ACC (X-ray 2.21A ) 4ACD (X-ray 2.60A ) 4ACG (X-ray 2.60A ) 4ACH (X-ray 2.60A ) 4AFJ (X-ray 1.98A ) 4B7T (X-ray 2.77A ) 4DIT (X-ray 2.60A ) 4EKK (X-ray 2.80A ) 4IQ6 (X-ray 3.12A ) 4J1R (X-ray 2.70A ) 4J71 (X-ray 2.31A ) 4NM0 (X-ray 2.50A ) 4NM3 (X-ray 2.10A ) 4NM5 (X-ray 2.30A ) 4NM7 (X-ray 2.30A ) 4PTC (X-ray 2.71A ) 4PTE (X-ray 2.03A ) 4PTG (X-ray 2.36A ) 5F94 (X-ray 2.51A ) 5F95 (X-ray 2.52A ) 5HLN (X-ray 3.10A ) 5HLP (X-ray 2.45A ) 5K5N (X-ray 2.20A ) 5KPK (X-ray 2.40A ) 5KPL (X-ray 2.60A ) 5KPM (X-ray 2.69A ) 5OY4 (X-ray 3.20A ) 5T31 (X-ray 2.85A ) 6B8J (X-ray 2.60A ) 6BUU (X-ray 2.40A ) 6GJO (X-ray 2.91A ) 6GN1 (X-ray 2.60A ) 6H0U (X-ray 2.30A ) 6HK3 (X-ray 2.35A ) 6HK4 (X-ray 2.50A ) 6HK7 (X-ray 3.20A ) 6NPZ (X-ray 2.12A ) 6TCU (X-ray 2.14A ) 6V6L (X-ray 2.19A ) 6Y9R (X-ray 2.08A ) 6Y9S (X-ray 2.03A ) 7B6F (X-ray 2.05A ) 7OY5 (X-ray 2.57A ) 7U2Z (X-ray 2.21A ) 7U31 (X-ray 2.38A ) 7U33 (X-ray 2.60A ) 7U36 (X-ray 2.75A ) |
| DBSNP | NA |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:21029237, ECO:0000269|PubMed:25169422}. Nucleus {ECO:0000269|PubMed:15448698, ECO:0000269|PubMed:21029237}. Cell membrane {ECO:0000269|PubMed:20937854}. Note=The phosphorylated form shows localization to cytoplasm and cell membrane (PubMed:20937854). The MEMO1-RHOA-DIAPH1 signaling pathway controls localization of the phosphorylated form to the cell membrane (PubMed:20937854). {ECO:0000269|PubMed:20937854}. |
| Mouse PG classification | NA |
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