| Gene Information | |
|---|---|
| Gene Name | GSG2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 798 |
| Protein Names | Serine/threonine-protein kinase haspin (EC 2.7.11.1) (Germ cell-specific gene 2 protein) (H-haspin) (Haploid germ cell-specific nuclear protein kinase) |
| Target Name | serine/threonine-protein kinase haspin |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | Q8TF76 |
| Gene Card | HASPIN |
| Uniprot ID | Q8TF76 |
| Pfam | NA |
| In ASD | yes |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Strongly expressed in testis. Also present in thymus and bone marrow and low levels observed in prostate, intestine, lung, spleen and lymph node. Expressed in fetal skin, liver, kidney and small intestine and also in proliferating but not non-proliferating cell lines. {ECO:0000269|PubMed:11228240, ECO:0000269|PubMed:11311556}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2VUW (X-ray 1.80A ) 2WB8 (X-ray 2.15A ) 3DLZ (X-ray 1.85A ) 3E7V (X-ray 2.00A ) 3F2N (X-ray 1.80A ) 3FMD (X-ray 2.00A ) 3IQ7 (X-ray 2.00A ) 4OUC (X-ray 1.90A ) 4QTC (X-ray 1.40A ) 5HTB (X-ray 1.70A ) 5HTC (X-ray 1.50A ) 6G34 (X-ray 1.76A ) 6G35 (X-ray 1.55A ) 6G36 (X-ray 1.46A ) 6G37 (X-ray 1.48A ) 6G38 (X-ray 1.47A ) 6G39 (X-ray 1.45A ) 6G3A (X-ray 1.43A ) 6Z56 (X-ray 1.90A ) 6Z57 (X-ray 1.50A ) 6Z58 (X-ray 1.80A ) 6Z59 (X-ray 2.00A ) 6Z5A (X-ray 1.55A ) 6Z5B (X-ray 1.90A ) 6Z5C (X-ray 1.75A ) 6Z5D (X-ray 1.75A ) 6Z5E (X-ray 1.50A ) 7AVQ (X-ray 1.65A ) 7OPS (X-ray 2.38A ) 7SQM (X-ray 1.78A ) |
| DBSNP | rs11653889 rs9907144 rs55991903 rs220462 rs56224301 rs55649477 rs220461 rs3809806 rs7223226 rs56134695 |
| Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:15681610}. Chromosome {ECO:0000269|PubMed:15681610}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:15681610}. Note=Nuclear during interphase and associates with the chromosomes and spindle apparatus during mitosis. |
| Mouse PG classification | NA |
| click here to return to the previous page | |