| Gene Information | |
|---|---|
| Gene Name | GSDME |
| Organism | Homo sapiens (Human) |
| Gene Length | 496 |
| Protein Names | Gasdermin-E (Inversely correlated with estrogen receptor expression 1) (ICERE-1) (Non-syndromic hearing impairment protein 5) [Cleaved into: Gasdermin-E, N-terminal (GSDME-NT); Gasdermin-E, C-terminal (GSDME-CT)] |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 544 ( ENSG00000105928 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | O60443 |
| Gene Card | GSDME |
| Uniprot ID | O60443 |
| Pfam | PF04598; PF17708 |
| In ASD | no |
| Allosteric Prediction | no (-1.64596561) |
| Ortholog in Animals | Alpaca_ GSDME ( ortholog_one2one ) Dog_ GSDME ( ortholog_one2one ) GuineaPig_ GSDME ( ortholog_one2one ) Macaque_ GSDME ( ortholog_one2one ) Mouse_ Gsdme ( ortholog_one2one ) Pig_ GSDME ( ortholog_one2one ) Rat_ Gsdme ( ortholog_one2one ) Rabbit_ GSDME ( ortholog_one2one ) |
| Ohnologs | PJVK |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Expressed in cochlea (PubMed:9771715). Low level of expression in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas, with highest expression in placenta (PubMed:9771715). {ECO:0000269|PubMed:9771715}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs754554 rs876306 rs12540919 |
| Subcellular location [CC] | [Gasdermin-E, N-terminal]: Cell membrane {ECO:0000269|PubMed:28045099, ECO:0000269|PubMed:28459430}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q5Y4Y6}.; [Gasdermin-E]: Cytoplasm, cytosol {ECO:0000269|PubMed:28045099}. |
| Mouse PG classification | NA |
| click here to return to the previous page | |