| Gene Information | |
|---|---|
| Gene Name | GSDMD |
| Organism | Homo sapiens (Human) |
| Gene Length | 484 |
| Protein Names | Gasdermin-D (Gasdermin domain-containing protein 1) [Cleaved into: Gasdermin-D, N-terminal (GSDMD-NT) (hGSDMD-NTD); Gasdermin-D, C-terminal (GSDMD-CT) (hGSDMD-CTD)] |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000104518 ) 3 ( ENSG00000278718 ) |
| Evolutionary Stage | Mammalia |
| AlphaFoldDB | P57764 |
| Gene Card | GSDMD |
| Uniprot ID | P57764 |
| Pfam | PF04598; PF17708 |
| In ASD | no |
| Allosteric Prediction | yes (0.111304794) |
| Ortholog in Animals | Alpaca_ GSDMD ( ortholog_one2one ) Dog_ GSDMD ( ortholog_one2one ) GuineaPig_ GSDMD ( ortholog_one2one ) Macaque_ GSDMD ( ortholog_one2one ) Mouse_ Gsdmd ( ortholog_one2one ) Pig_ GSDMD ( ortholog_one2one ) Rat_ Gsdmd ( ortholog_one2one ) Rabbit_ GSDMD ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | GSDMA, GSDMC, GSDMB, PJVK |
| Tissue | NA |
| Tissue Specificity | Expressed in the suprabasal cells of esophagus, as well as in the isthmus/neck, pit, and gland of the stomach, suggesting preferential expression in differentiating cells. {ECO:0000269|PubMed:19051310}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001000(Rat);0.1(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 5NH1 (X-ray 2.04A ) 5WQT (X-ray 2.64A ) 6AO4 (X-ray 2.90A ) 6KN0 (X-ray 2.79A ) 6N9O (X-ray 3.50A ) 6VFE (EM 3.90A ) |
| DBSNP | NA |
| Subcellular location [CC] | [Gasdermin-D]: Cytoplasm, cytosol {ECO:0000269|PubMed:27281216}. Inflammasome {ECO:0000250|UniProtKB:Q9D8T2}. Note=In response to a canonical inflammasome stimulus, such as nigericin, recruited to NLRP3 inflammasone with similar kinetics to that of uncleaved CASP1 precursor. {ECO:0000250|UniProtKB:Q9D8T2}.; [Gasdermin-D, N-terminal]: Cell membrane {ECO:0000269|PubMed:27281216, ECO:0000269|PubMed:32109412, ECO:0000269|PubMed:33883744}; Multi-pass membrane protein {ECO:0000269|PubMed:33883744, ECO:0000305|PubMed:29898893}. Secreted {ECO:0000250|UniProtKB:Q9D8T2}. Note=Released in the extracellular milieu following pyroptosis. {ECO:0000250|UniProtKB:Q9D8T2}.; [Gasdermin-D, C-terminal]: Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q9D8T2}. |
| Mouse PG classification | NA |
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