| Gene Information | |
|---|---|
| Gene Name | DMKN |
| Organism | Homo sapiens (Human) |
| Gene Length | 476 |
| Protein Names | Dermokine (Epidermis-specific secreted protein SK30/SK89) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 132 ( ENSG00000161249 ) |
| Evolutionary Stage | Mammalia |
| AlphaFoldDB | Q6E0U4 |
| Gene Card | DMKN |
| Uniprot ID | Q6E0U4 |
| Pfam | NA |
| In ASD | no |
| Allosteric Prediction | no (-0.920017159) |
| Ortholog in Animals | Alpaca_ DMKN ( ortholog_one2one ) Mouse_ Dmkn ( ortholog_one2one ) Rat_ Dmkn ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | skin |
| Tissue Specificity | Expressed in epidermis; in the spinous and granular layers and in placenta. Also found in the epithelia of the small intestine, macrophages of the lung and endothelial cells of the lung. Isoform 15 is expressed in epidermis and placenta. Isoform 1 is expressed in epidermis. {ECO:0000269|PubMed:16374476, ECO:0000269|PubMed:17380110}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 4F20 (X-ray 2.50A ) |
| DBSNP | rs12460932 rs4806163 rs7247001 rs11667007 rs2293696 rs909072 |
| Subcellular location [CC] | Secreted {ECO:0000269|PubMed:15234001}. |
| Mouse PG classification | NA |
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