| Gene Information | |
|---|---|
| Gene Name | TACC3 |
| Organism | Homo sapiens (Human) |
| Gene Length | 838 |
| Protein Names | Transforming acidic coiled-coil-containing protein 3 (ERIC-1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000013810 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q9Y6A5 |
| Gene Card | TACC3 |
| Uniprot ID | Q9Y6A5 |
| Pfam | PF05010 |
| In ASD | no |
| Allosteric Prediction | no (-0.453883895) |
| Ortholog in Animals | Alpaca_ TACC3 ( ortholog_one2one ) Dog_ TACC3 ( ortholog_one2one ) GuineaPig_ TACC3 ( ortholog_one2one ) Macaque_ TACC3 ( ortholog_one2one ) Mouse_ Tacc3 ( ortholog_one2one ) Rat_ Tacc3 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | TACC2, TACC1 |
| Tissue | appendix, testis, spleen, whole.blood |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 5LXN (X-ray 2.08A ) 5LXO (X-ray 2.18A ) 5ODS (X-ray 3.09A ) 5ODT (X-ray 2.02A ) |
| DBSNP | rs34205238 rs17132047 rs1063743 rs17680881 |
| Subcellular location [CC] | Cytoplasm {ECO:0000250}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:17545617}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:17545617, ECO:0000269|PubMed:21297582, ECO:0000269|PubMed:23918938}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000250|UniProtKB:Q9PTG8}. Note=In complex with CKAP5 localized to microtubule plus-ends in mitosis and interphase. In complex with CKAP5 and clathrin localized to inter-microtubule bridges in mitotic spindles. {ECO:0000269|PubMed:25596274}. |
| Mouse PG classification | NA |
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