| Gene Information | |
|---|---|
| Gene Name | GSDM |
| Organism | Homo sapiens (Human) |
| Gene Length | 445 |
| Protein Names | Gasdermin-A (Gasdermin-1) [Cleaved into: Gasdermin-A, N-terminal (GSDMA-NT); Gasdermin-A, C-terminal (GSDMA-CT)] |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | Q96QA5 |
| Gene Card | GSDMA |
| Uniprot ID | Q96QA5 |
| Pfam | PF04598; PF17708 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Expressed predominantly in the gastrointestinal tract and, at a lower level, in the skin. Also detected in mammary gland. In the gastrointestinal tract, mainly expressed in differentiated cells, including the differentiated cell layer of esophagus and mucus-secreting pit cells of the gastric epithelium. Down-regulateded in gastric cancer cells. {ECO:0000269|PubMed:10967128, ECO:0000269|PubMed:17471240, ECO:0000269|PubMed:19051310}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs3894194 rs7212938 rs7212944 rs56030650 |
| Subcellular location [CC] | [Gasdermin-A]: Cytoplasm, perinuclear region {ECO:0000269|PubMed:17471240}. Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q5Y4Y6}.; [Gasdermin-A, N-terminal]: Cell membrane {ECO:0000269|PubMed:35110732, ECO:0000269|PubMed:35545676}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q5Y4Y6}. |
| Mouse PG classification | NA |
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