| Gene Information | |
|---|---|
| Gene Name | AGRN |
| Organism | Homo sapiens (Human) |
| Gene Length | 2068 |
| Protein Names | Agrin [Cleaved into: Agrin N-terminal 110 kDa subunit; Agrin C-terminal 110 kDa subunit; Agrin C-terminal 90 kDa fragment (C90); Agrin C-terminal 22 kDa fragment (C22)] |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000188157 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | O00468 |
| Gene Card | AGRN |
| Uniprot ID | O00468 |
| Pfam | PF00008; PF00050; PF07648; PF00053; PF00054; PF03146; PF01390 |
| In ASD | no |
| Allosteric Prediction | yes (0.098340472) |
| Ortholog in Animals | Alpaca_ AGRN ( ortholog_one2many ) Dog_ AGRN ( ortholog_one2one ) GuineaPig_ AGRN ( ortholog_one2one ) Macaque_ AGRN ( ortholog_one2one ) Mouse_ Agrn ( ortholog_one2one ) Pig_ AGRN ( ortholog_one2one ) Rat_ Agrn ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | LAMB2, LAMC3, NTN4, LAMB1, LAMA3, LAMC1, ATRNL1, LAMA2, TMEFF2, ATRN, NTN1, NTN3, LAMC2, TMEFF1, LAMA1, LAMB4, NTNG2, NTNG1, LAMA4, MEGF9, MEGF8, LAMB3, EGFLAM, LAMA5, NTN5, USH2A, HSPG2 |
| Tissue | NA |
| Tissue Specificity | Expressed in basement membranes of lung and kidney. Muscle- and neuron-specific isoforms are found. Isoforms (y+) with the 4 AA insert and (z+8) isoforms with the 8 AA insert are all neuron-specific. Isoforms (z+11) are found in both neuronal and non-neuronal tissues. {ECO:0000269|PubMed:16487930, ECO:0000269|PubMed:20551380, ECO:0000269|PubMed:9652404}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | NA |
| DBSNP | rs138031468 rs113288277 rs9697293 rs150132566 rs149159118 rs142416636 rs142620337 rs111818381 rs199876002 rs17160775 rs145444272 |
| Subcellular location [CC] | [Isoform 1]: Secreted, extracellular space, extracellular matrix {ECO:0000269|PubMed:20551380}. Note=Synaptic basal lamina at the neuromuscular junction. {ECO:0000250|UniProtKB:P31696}.; [Isoform 2]: Synapse {ECO:0000250|UniProtKB:A2ASQ1}. Cell membrane {ECO:0000250|UniProtKB:A2ASQ1}; Single-pass type II membrane protein {ECO:0000250|UniProtKB:A2ASQ1}. |
| Mouse PG classification | NA |
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