| Gene Information | |
|---|---|
| Gene Name | GRPR |
| Organism | Homo sapiens (Human) |
| Gene Length | 384 |
| Protein Names | Gastrin-releasing peptide receptor (GRP-R) (GRP-preferring bombesin receptor) |
| Target Name | gastrin-releasing peptide receptor |
| Target Type | Clinical trial target |
| Gene Age | 645 ( ENSG00000126010 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | P30550 |
| Gene Card | GRPR |
| Uniprot ID | P30550 |
| Pfam | PF00001 |
| In ASD | no |
| Allosteric Prediction | yes (0.97614324) |
| Ortholog in Animals | Alpaca_ GRPR ( ortholog_one2one ) Dog_ GRPR ( ortholog_one2one ) GuineaPig_ GRPR ( ortholog_one2one ) Macaque_ GRPR ( ortholog_one2one ) Mouse_ Grpr ( ortholog_one2one ) Pig_ GRPR ( ortholog_one2one ) Rat_ Grpr ( ortholog_one2one ) Rabbit_ GRPR ( ortholog_one2one ) |
| Ohnologs | BRS3, NMBR |
| Paralogs | BRS3, NMBR, EDNRA, EDNRB, NTSR1, GHSR, NMUR2, NTSR2, GPR39, NMUR1, MLNR, GPR37, TRHR, GPR148, GPR37L1 |
| Tissue | NA |
| Tissue Specificity | Highly expressed in pancreas (PubMed:11245983). Also expressed in stomach, adrenal cortex and brain (PubMed:11245983). In brain, expressed in cells throughout the cortex (PubMed:34610277). {ECO:0000269|PubMed:11245983, ECO:0000269|PubMed:34610277}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | NA |
| DBSNP | NA |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:1655761}; Multi-pass membrane protein {ECO:0000255}. |
| Mouse PG classification | NA |
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