| Gene Information | |
|---|---|
| Gene Name | GRM8 |
| Organism | Homo sapiens (Human) |
| Gene Length | 908 |
| Protein Names | Metabotropic glutamate receptor 8 (mGluR8) |
| Target Name | metabotropic glutamate receptor 8 |
| Target Type | Literature-reported target |
| Gene Age | 544 ( ENSG00000179603 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | O00222 |
| Gene Card | GRM8 |
| Uniprot ID | O00222 |
| Pfam | PF00003; PF01094; PF07562 |
| In ASD | yes |
| Allosteric Prediction | yes (1.171539461) |
| Ortholog in Animals | Alpaca_ GRM8 ( ortholog_one2one ) Dog_ GRM8 ( ortholog_one2one ) Macaque_ GRM8 ( ortholog_one2one ) Mouse_ Grm8 ( ortholog_one2one ) Pig_ GRM8 ( ortholog_one2one ) Rat_ Grm8 ( ortholog_one2one ) Rabbit_ GRM8 ( ortholog_one2one ) |
| Ohnologs | GRM3, GRM4, GRM1, GRM2, GRM7 |
| Paralogs | GRM2, GRM1, GRM5, GRM3, GRM4, GRM6, GRM7 |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 6BSZ (X-ray 2.65A ) 6BT5 (X-ray 2.92A ) 6E5V (X-ray 2.95A ) |
| DBSNP | rs769194 rs769202 rs17150343 rs13309334 rs78124913 rs78947184 rs2234947 rs75863532 rs2234948 rs1051433 rs10225567 |
| Subcellular location [CC] | Cell membrane; Multi-pass membrane protein. |
| Mouse PG classification | NA |
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