| Gene Information | |
|---|---|
| Gene Name | GRM6 |
| Organism | Homo sapiens (Human) |
| Gene Length | 877 |
| Protein Names | Metabotropic glutamate receptor 6 (mGluR6) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 454 ( ENSG00000113262 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | O15303 |
| Gene Card | GRM6 |
| Uniprot ID | O15303 |
| Pfam | PF00003; PF01094; PF07562 |
| In ASD | no |
| Allosteric Prediction | yes (0.76117315) |
| Ortholog in Animals | Alpaca_ GRM6 ( ortholog_one2one ) Dog_ GRM6 ( ortholog_one2one ) GuineaPig_ GRM6 ( ortholog_one2one ) Macaque_ GRM6 ( ortholog_one2one ) Mouse_ Grm6 ( ortholog_one2one ) Pig_ GRM6 ( ortholog_one2one ) Rat_ Grm6 ( ortholog_one2one ) Rabbit_ GRM6 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | GRM2, GRM1, GRM5, GRM3, GRM8, GRM4, GRM7 |
| Tissue | NA |
| Tissue Specificity | Detected in melanocytes. {ECO:0000269|PubMed:23452348}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs62638197 rs62638198 rs2645329 rs62638202 rs17078898 rs17078896 rs121434304 rs62638208 rs17078877 rs62638625 rs17078874 rs17078857 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:17405131}; Multi-pass membrane protein {ECO:0000269|PubMed:17405131}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:17405131}; Multi-pass membrane protein {ECO:0000269|PubMed:17405131}. Golgi apparatus membrane {ECO:0000269|PubMed:17405131}; Multi-pass membrane protein {ECO:0000269|PubMed:17405131}. Cell projection, dendrite {ECO:0000250}. Note=Subject to trafficking from the endoplasmic reticulum to the Golgi apparatus and then to the cell membrane. |
| Mouse PG classification | NA |
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