Gene Information
Gene NameGRM5
OrganismHomo sapiens (Human)
Gene Length1212
Protein NamesMetabotropic glutamate receptor 5 (mGluR5)
Target Namemetabotropic glutamate receptor 5
Target TypeNA
Gene Age987 ( ENSG00000168959 )
Evolutionary StageVertebrata
AlphaFoldDBP41594
Gene CardGRM5
Uniprot IDP41594
PfamPF00003; PF01094; PF10606; PF07562
In ASDyes
Allosteric Predictionyes (1.48342695)
Ortholog in AnimalsAlpaca_ GRM5 ( ortholog_one2one )
Dog_ GRM5 ( ortholog_one2one )
GuineaPig_ GRM5 ( ortholog_one2one )
Macaque_ GRM5 ( ortholog_one2one )
Mouse_ Grm5 ( ortholog_one2one )
Pig_ GRM5 ( ortholog_one2one )
Rat_ Grm5 ( ortholog_one2one )
Rabbit_ GRM5 ( ortholog_one2one )
OhnologsGRM1, GRM2, GRM7
ParalogsGRM1, GRM2, GRM3, GRM7, GRM6, GRM8, GRM4
Tissuebrain
Tissue SpecificityNA
Pharmacological Animal ModelsNULL(Chimpanzee);NULL(Mouse);0.004740(Rat);0.075000(Rabbit)
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 3LMK  (X-ray  2.44A  4OO9  (X-ray  2.60A  5CGC  (X-ray  3.10A  5CGD  (X-ray  2.60A  6N4X  (X-ray  4.00A  6N4Y  (X-ray  3.26A  6N50  (X-ray  3.75A  6N51  (EM  4.00A  6N52  (EM  4.00A  7FD8  (EM  3.80A  7FD9  (EM  4.00A 
DBSNP NA 
Subcellular location [CC]Cell membrane {ECO:0000269|PubMed:25042998, ECO:0000269|PubMed:7908515};
Multi-pass membrane protein {ECO:0000269|PubMed:25042998, ECO:0000269|PubMed:7908515}.
Mouse PG classificationNA
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