| Gene Information | |
|---|---|
| Gene Name | GRM5 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1212 |
| Protein Names | Metabotropic glutamate receptor 5 (mGluR5) |
| Target Name | metabotropic glutamate receptor 5 |
| Target Type | Clinical trial target |
| Gene Age | 987 ( ENSG00000168959 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | P41594 |
| Gene Card | GRM5 |
| Uniprot ID | P41594 |
| Pfam | PF00003; PF01094; PF10606; PF07562 |
| In ASD | yes |
| Allosteric Prediction | yes (1.48342695) |
| Ortholog in Animals | Alpaca_ GRM5 ( ortholog_one2one ) Dog_ GRM5 ( ortholog_one2one ) GuineaPig_ GRM5 ( ortholog_one2one ) Macaque_ GRM5 ( ortholog_one2one ) Mouse_ Grm5 ( ortholog_one2one ) Pig_ GRM5 ( ortholog_one2one ) Rat_ Grm5 ( ortholog_one2one ) Rabbit_ GRM5 ( ortholog_one2one ) |
| Ohnologs | GRM1, GRM2, GRM7 |
| Paralogs | GRM1, GRM2, GRM3, GRM7, GRM6, GRM8, GRM4 |
| Tissue | brain |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.004740(Rat);0.075000(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
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| PDB | 3LMK (X-ray 2.44A ) 4OO9 (X-ray 2.60A ) 5CGC (X-ray 3.10A ) 5CGD (X-ray 2.60A ) 6N4X (X-ray 4.00A ) 6N4Y (X-ray 3.26A ) 6N50 (X-ray 3.75A ) 6N51 (EM 4.00A ) 6N52 (EM 4.00A ) 7FD8 (EM 3.80A ) 7FD9 (EM 4.00A ) |
| DBSNP | NA |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:25042998, ECO:0000269|PubMed:7908515}; Multi-pass membrane protein {ECO:0000269|PubMed:25042998, ECO:0000269|PubMed:7908515}. |
| Mouse PG classification | NA |
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