| Gene Information | |
|---|---|
| Gene Name | GRM4 |
| Organism | Homo sapiens (Human) |
| Gene Length | 912 |
| Protein Names | Metabotropic glutamate receptor 4 (mGluR4) |
| Target Name | metabotropic glutamate receptor 4 |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000124493 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q14833 |
| Gene Card | GRM4 |
| Uniprot ID | Q14833 |
| Pfam | PF00003; PF01094; PF07562 |
| In ASD | yes |
| Allosteric Prediction | yes (1.449049833) |
| Ortholog in Animals | Alpaca_ GRM4 ( ortholog_one2one ) Dog_ GRM4 ( ortholog_one2one ) GuineaPig_ GRM4 ( ortholog_one2one ) Macaque_ GRM4 ( ortholog_one2one ) Mouse_ Grm4 ( ortholog_one2one ) Pig_ GRM4 ( ortholog_one2one ) Rat_ Grm4 ( ortholog_one2one ) Rabbit_ GRM4 ( ortholog_one2one ) |
| Ohnologs | GRM8, GRM3, GRM2, GRM7 |
| Paralogs | GRM2, GRM1, GRM5, GRM3, GRM8, GRM6, GRM7 |
| Tissue | cerebellar.hemisphere, cerebellum |
| Tissue Specificity | Strongly expressed in the cerebellum. Expressed at low levels in hippocampus, hypothalamus and thalamus. No expression detected in liver. {ECO:0000269|PubMed:7617140, ECO:0000269|PubMed:8738157}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 7E9H (EM 4.00A ) |
| DBSNP | rs452752 rs149730753 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:7617140, ECO:0000269|PubMed:8738157}; Multi-pass membrane protein {ECO:0000269|PubMed:7617140, ECO:0000269|PubMed:8738157}. |
| Mouse PG classification | NA |
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