| Gene Information | |
|---|---|
| Gene Name | KSR2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 950 |
| Protein Names | Kinase suppressor of Ras 2 (hKSR2) (EC 2.7.11.1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 987 ( ENSG00000171435 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q6VAB6 |
| Gene Card | KSR2 |
| Uniprot ID | Q6VAB6 |
| Pfam | PF07714; PF13543; PF20406 |
| In ASD | yes |
| Allosteric Prediction | yes (0.742789236) |
| Ortholog in Animals | Alpaca_ KSR2 ( ortholog_one2one ) Dog_ KSR2 ( ortholog_one2one ) GuineaPig_ KSR2 ( ortholog_one2one ) Macaque_ KSR2 ( ortholog_one2one ) Mouse_ Ksr2 ( ortholog_one2one ) Pig_ KSR2 ( ortholog_one2one ) Rat_ Ksr2 ( ortholog_one2one ) Rabbit_ KSR2 ( ortholog_one2one ) |
| Ohnologs | KSR1 |
| Paralogs | LIMK2, RIPK1, LRRK2, TNNI3K, TESK2, MAP3K10, RIPK2, MOS, MAP3K9, MLKL, MAP3K20, ARAF, TESK1, MAP3K13, BRAF, ILK, MAP3K11, RAF1, MAP3K12, MAP3K21, LIMK1, KSR1, RIPK3 |
| Tissue | NA |
| Tissue Specificity | Mainly expressed in brain and kidney. {ECO:0000269|PubMed:12975377}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 2Y4I (X-ray 3.46A ) 5KKR (X-ray 3.51A ) 7JUQ (X-ray 3.22A ) 7JUR (X-ray 2.82A ) 7JUS (X-ray 2.99A ) 7JUT (X-ray 3.09A ) 7JUU (X-ray 3.19A ) 7JUV (X-ray 3.36A ) |
| DBSNP | NA |
| Subcellular location [CC] | Cytoplasm {ECO:0000250}. Membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. |
| Mouse PG classification | NA |
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