| Gene Information | |
|---|---|
| Gene Name | GRM3 |
| Organism | Homo sapiens (Human) |
| Gene Length | 879 |
| Protein Names | Metabotropic glutamate receptor 3 (mGluR3) |
| Target Name | metabotropic glutamate receptor 3 |
| Target Type | Clinical trial target |
| Gene Age | 987 ( ENSG00000198822 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q14832 |
| Gene Card | GRM3 |
| Uniprot ID | Q14832 |
| Pfam | PF00003; PF01094; PF07562 |
| In ASD | yes |
| Allosteric Prediction | yes (1.194755821) |
| Ortholog in Animals | Alpaca_ GRM3 ( ortholog_one2one ) GuineaPig_ GRM3 ( ortholog_one2one ) Macaque_ GRM3 ( ortholog_one2one ) Mouse_ Grm3 ( ortholog_one2one ) Pig_ GRM3 ( ortholog_one2one ) Rat_ Grm3 ( ortholog_one2one ) Rabbit_ GRM3 ( ortholog_one2one ) |
| Ohnologs | GRM4, GRM2, GRM8 |
| Paralogs | GRM2, GRM1, GRM5, GRM7, GRM6, GRM8, GRM4 |
| Tissue | brain, cerebral.cortex, amygdala, caudate.nucleus, hippocampus, nucleus.accumbens, putamen, substantia.nigra |
| Tissue Specificity | Detected in brain cortex, thalamus, subthalamic nucleus, substantia nigra, hypothalamus, hippocampus, corpus callosum, caudate nucleus and amygdala. {ECO:0000269|PubMed:8840013}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 3SM9 (X-ray 2.26A ) 4XAR (X-ray 2.26A ) 5CNK (X-ray 3.15A ) 5CNM (X-ray 2.84A ) 6B7H (X-ray 2.82A ) 7WI6 (EM 3.71A ) 7WI8 (EM 4.17A ) 7WIH (EM 3.68A ) |
| DBSNP | rs17161026 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:8840013}; Multi-pass membrane protein {ECO:0000269|PubMed:8840013}. |
| Mouse PG classification | NA |
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