| Gene Information | |
|---|---|
| Gene Name | GRM1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1194 |
| Protein Names | Metabotropic glutamate receptor 1 (mGluR1) |
| Target Name | metabotropic glutamate receptor 1 |
| Target Type | NA |
| Gene Age | 987 ( ENSG00000152822 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q13255 |
| Gene Card | GRM1 |
| Uniprot ID | Q13255 |
| Pfam | PF00003; PF01094; PF10606; PF07562 |
| In ASD | yes |
| Allosteric Prediction | yes (1.672958607) |
| Ortholog in Animals | Alpaca_ GRM1 ( ortholog_one2one ) Dog_ GRM1 ( ortholog_one2one ) GuineaPig_ GRM1 ( ortholog_one2one ) Macaque_ GRM1 ( ortholog_one2one ) Mouse_ Grm1 ( ortholog_one2one ) Pig_ GRM1 ( ortholog_one2one ) Rat_ Grm1 ( ortholog_one2one ) Rabbit_ GRM1 ( ortholog_one2one ) |
| Ohnologs | GRM5, GRM8 |
| Paralogs | GRM5, GRM2, GRM3, GRM7, GRM6, GRM8, GRM4 |
| Tissue | cerebellar.hemisphere, cerebellum |
| Tissue Specificity | Detected in brain. {ECO:0000269|PubMed:9076744}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.004740(Rat);0.100000(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 3KS9 (X-ray 1.90A ) 4OR2 (X-ray 2.80A ) 7DGD (EM 3.96A ) 7DGE (EM 3.65A ) |
| DBSNP | rs12190109 rs1554274719 rs7760248 rs1047005 rs1450433570 rs3025919 rs1554308513 rs362936 rs2941 rs6923492 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:24603153}; Multi-pass membrane protein {ECO:0000269|PubMed:24603153}. |
| Mouse PG classification | NA |
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